gene

HCRTR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCRTR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

355Connections
0Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

HCRTR1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Cardiovascular. Connected to 56 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHCRT1
Full NameHCRTR1
Protein TypeGene
FunctionThe HCRT1 (Hypocretin/Orexin 1) gene encodes the orexin-A neuropeptide, a critical regulator of arousal, wakefulness, and energy homeostasis
Amino Acids33 aa
PathwaysSleep-Wake Regulation
NCBI Gene IDSearch NCBI
GeneCardsHCRT1
Human Protein AtlasHCRT1
Associated DiseasesALS, Narcolepsy, Sleep Disorder
InteractionsOXR1
KG Connections21 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING
🔮 Predicted Structure: HCRTR1 — AlphaFold A6NMV7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

HCRTR1

gene · 765 words

coq10-neurodegeneration

therapeutic · 5142 words

omega-3-fatty-acids-neurodegeneration

therapeutic · 4551 words

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

therapeutic · 4539 words

Coenzyme Q10 for Neurodegeneration

therapeutic · 4452 words

deferiprone-neurodegeneration

therapeutic · 4392 words

Pathway Diagram

graph TD
    HCRTR1["<b>HCRTR1</b>"]
    Sleep_Wake_Transition(["Sleep-Wake Transition"])
    HCRTR1 -->|"associated with"| Sleep_Wake_Transition
    Hemodynamic_Stability["Hemodynamic Stability"]
    HCRTR1 -->|"associated with"| Hemodynamic_Stability
    Propofol["Propofol"]
    HCRTR1 -->|"interacts with"| Propofol
    neurodegeneration{"neurodegeneration"}
    HCRTR1 -->|"associated with"| neurodegeneration
    HCRTR2["HCRTR2"]
    HCRTR1 -->|"interacts with"| HCRTR2
    Als{"Als"}
    HCRTR1 -->|"associated with"| Als
    Obesity{"Obesity"}
    HCRTR1 -->|"therapeutic target"| Obesity
    Ms{"Ms"}
    HCRTR1 -->|"associated with"| Ms
    Diabetes{"Diabetes"}
    HCRTR1 -->|"associated with"| Diabetes
    Cardiovascular{"Cardiovascular"}
    HCRTR1 -->|"associated with"| Cardiovascular
    HCRTR1 -->|"activates"| Ms
    HCRTR1 -->|"activates"| Als
    h_9e9fee95["h-9e9fee95"]
    h_9e9fee95 -->|"therapeutic target"| HCRTR1
    h_9e9fee95 -->|"targets"| HCRTR1
    HCRTR2 -->|"interacts with"| HCRTR1
    HCRTR2 -->|"regulates"| HCRTR1
    HCRTR2 -->|"therapeutic target"| HCRTR1
    PNOC["PNOC"]
    PNOC -->|"therapeutic target"| HCRTR1
    TRPC6["TRPC6"]
    TRPC6 -->|"therapeutic target"| HCRTR1
    HCRTR2 -->|"associated with"| HCRTR1
    DRD2["DRD2"]
    DRD2 -->|"activates"| HCRTR1
    HRH3["HRH3"]
    HRH3 -->|"activates"| HCRTR1
    HCRTR2 -->|"activates"| HCRTR1
    ADRA1B["ADRA1B"]
    ADRA1B -->|"activates"| HCRTR1
    style HCRTR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (243)

TargetRelationTypeStr
Overall Survivalbiomarker_forphenotype0.90
Relapse Free Survivalbiomarker_forphenotype0.90
HCRTR2co_mentioned_withgene0.90
Sleep-Wake Transitionassociated_withprocess0.85
Sleep-Wake Transitionregulatesprocess0.85

Incoming (112)

SourceRelationTypeStr
Orexinergic Neuronsexpressed_incell_type0.92
HCRTco_mentioned_withgene0.90
NEURONinteracts_withcell_type0.90
h-9e9fee95targets_genehypothesis0.90
h-9e9fee95targetshypothesis0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found