gene

HCRTR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCRTR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

325Connections
1Hypotheses
3Analyses
50Outgoing
50Incoming
0Experiments
3Debates

Summary

HCRTR1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Cardiovascular. Connected to 56 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHCRT1
Full NameHCRTR1
Protein TypeGpcr
Target ClassGpcr
FunctionSmall molecule antagonist blocking orexin receptor signaling
Mechanism of ActionSmall molecule antagonist blocking orexin receptor signaling
DruggabilityMedium (0.60)
Clinical StageApproved
Amino Acids33 aa
PathwaysCircadian rhythm / glymphatic clearance, NF-κB signaling, Sleep-Wake Transition
UniProt IDA6NMV7
GeneCardsHCRT1
Human Protein AtlasHCRT1
Orexin-A (Hypocretin-1)A 33-amino acid peptide with two disulfide bonds[@sakurai2007]
Orexin-B (Hypocretin-2)A 28-amino acid linear peptide[@sakurai2007]
Associated DiseasesAddiction, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsPropofol, suvorexant
Interactions5-HT1AR, ACE, ADRA1A, ADRA1B, AQP4, ASTROCYTE
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesDaytime orexin tone preserves synaptic plasticity
KG Connections322 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: HCRTR1 — AlphaFold A6NMV7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HCRTR1

gene · 765 words

Pathway Diagram

graph TD
    HCRTR1["HCRTR1"]
    Sleep_Wake_Transition(["Sleep-Wake Transition"])
    HCRTR1 -->|"associated with"| Sleep_Wake_Transition
    Hemodynamic_Stability["Hemodynamic Stability"]
    HCRTR1 -->|"associated with"| Hemodynamic_Stability
    Propofol["Propofol"]
    HCRTR1 -->|"interacts with"| Propofol
    neurodegeneration{"neurodegeneration"}
    HCRTR1 -->|"associated with"| neurodegeneration
    HCRTR2["HCRTR2"]
    HCRTR1 -->|"interacts with"| HCRTR2
    Als{"Als"}
    HCRTR1 -->|"associated with"| Als
    Obesity{"Obesity"}
    HCRTR1 -->|"therapeutic target"| Obesity
    Ms{"Ms"}
    HCRTR1 -->|"associated with"| Ms
    Diabetes{"Diabetes"}
    HCRTR1 -->|"associated with"| Diabetes
    Cardiovascular{"Cardiovascular"}
    HCRTR1 -->|"associated with"| Cardiovascular
    HCRTR1 -->|"activates"| Ms
    HCRTR1 -->|"activates"| Als
    h_9e9fee95["h-9e9fee95"]
    h_9e9fee95 -->|"therapeutic target"| HCRTR1
    h_9e9fee95 -->|"targets"| HCRTR1
    HCRTR2 -->|"interacts with"| HCRTR1
    HCRTR2 -->|"regulates"| HCRTR1
    HCRTR2 -->|"therapeutic target"| HCRTR1
    PNOC["PNOC"]
    PNOC -->|"therapeutic target"| HCRTR1
    TRPC6["TRPC6"]
    TRPC6 -->|"therapeutic target"| HCRTR1
    HCRTR2 -->|"associated with"| HCRTR1
    DRD2["DRD2"]
    DRD2 -->|"activates"| HCRTR1
    HRH3["HRH3"]
    HRH3 -->|"activates"| HCRTR1
    HCRTR2 -->|"activates"| HCRTR1
    ADRA1B["ADRA1B"]
    ADRA1B -->|"activates"| HCRTR1
    style HCRTR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (222)

TargetRelationTypeStr
orexin_signalingregulatespathway0.90
Overall Survivalbiomarker_forphenotype0.90
Relapse Free Survivalbiomarker_forphenotype0.90
HCRTR2associated_withgene0.90
Sleep-Wake Transitionregulatesprocess0.85

Incoming (103)

SourceRelationTypeStr
suvorexantinhibitsdrug0.95
Orexinergic Neuronsexpressed_incell_type0.92
HCRTassociated_withgene0.90
NEURONinteracts_withcell_type0.90
h-9e9fee95targetshypothesis0.90

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Daytime orexin tone preserves synaptic plasticity in prodrom 0.650 neurodegeneration Orexin-A manipulation in AD cognition an

Mentioning Analyses (3)

Scientific analyses that reference this entity

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.763

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.882

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Sleep disruption as cause and consequence of neurodegeneration

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

Perivascular spaces and glymphatic clearance failure in AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

What are the mechanisms underlying perivascular spaces and glymphatic clearance

closed · Rounds: 4 · Score: 0.93 · 2026-04-01

Related Research

Hypotheses and analyses mentioning HCRTR1 in their description or question text

No additional research found