Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HCRTR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HCRTR1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Cardiovascular. Connected to 56 entities in the SciDEX knowledge graph.
| Gene Symbol | HCRT1 |
| Full Name | HCRTR1 |
| Protein Type | Gene |
| Function | The HCRT1 (Hypocretin/Orexin 1) gene encodes the orexin-A neuropeptide, a critical regulator of arousal, wakefulness, and energy homeostasis |
| Amino Acids | 33 aa |
| Pathways | Sleep-Wake Regulation |
| NCBI Gene ID | Search NCBI |
| GeneCards | HCRT1 |
| Human Protein Atlas | HCRT1 |
| Associated Diseases | ALS, Narcolepsy, Sleep Disorder |
| Interactions | OXR1 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
HCRTR1["<b>HCRTR1</b>"]
Sleep_Wake_Transition(["Sleep-Wake Transition"])
HCRTR1 -->|"associated with"| Sleep_Wake_Transition
Hemodynamic_Stability["Hemodynamic Stability"]
HCRTR1 -->|"associated with"| Hemodynamic_Stability
Propofol["Propofol"]
HCRTR1 -->|"interacts with"| Propofol
neurodegeneration{"neurodegeneration"}
HCRTR1 -->|"associated with"| neurodegeneration
HCRTR2["HCRTR2"]
HCRTR1 -->|"interacts with"| HCRTR2
Als{"Als"}
HCRTR1 -->|"associated with"| Als
Obesity{"Obesity"}
HCRTR1 -->|"therapeutic target"| Obesity
Ms{"Ms"}
HCRTR1 -->|"associated with"| Ms
Diabetes{"Diabetes"}
HCRTR1 -->|"associated with"| Diabetes
Cardiovascular{"Cardiovascular"}
HCRTR1 -->|"associated with"| Cardiovascular
HCRTR1 -->|"activates"| Ms
HCRTR1 -->|"activates"| Als
h_9e9fee95["h-9e9fee95"]
h_9e9fee95 -->|"therapeutic target"| HCRTR1
h_9e9fee95 -->|"targets"| HCRTR1
HCRTR2 -->|"interacts with"| HCRTR1
HCRTR2 -->|"regulates"| HCRTR1
HCRTR2 -->|"therapeutic target"| HCRTR1
PNOC["PNOC"]
PNOC -->|"therapeutic target"| HCRTR1
TRPC6["TRPC6"]
TRPC6 -->|"therapeutic target"| HCRTR1
HCRTR2 -->|"associated with"| HCRTR1
DRD2["DRD2"]
DRD2 -->|"activates"| HCRTR1
HRH3["HRH3"]
HRH3 -->|"activates"| HCRTR1
HCRTR2 -->|"activates"| HCRTR1
ADRA1B["ADRA1B"]
ADRA1B -->|"activates"| HCRTR1
style HCRTR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Overall Survival | biomarker_for | phenotype | 0.90 |
| Relapse Free Survival | biomarker_for | phenotype | 0.90 |
| HCRTR2 | co_mentioned_with | gene | 0.90 |
| Sleep-Wake Transition | associated_with | process | 0.85 |
| Sleep-Wake Transition | regulates | process | 0.85 |
| BDNF | inhibits | protein | 0.85 |
| cognitive dysfunction | promotes | phenotype | 0.85 |
| Sleep-Wake Transition | involved_in | process | 0.85 |
| alcohol drinking | regulates | phenotype | 0.85 |
| CRF | interacts_with | protein | 0.85 |
| Interindividual Variability In Anesthetic Response | contributes_to | phenotype | 0.82 |
| Hemodynamic Stability | associated_with | phenotype | 0.80 |
| lactate production | inhibits | process | 0.80 |
| Time To Loss Of Consciousness | associated_with | phenotype | 0.80 |
| Time To Wake | associated_with | phenotype | 0.80 |
| Loss Of Consciousness | associated_with | phenotype | 0.80 |
| HCRTR2 | modulates | gene | 0.80 |
| BNST neuronal excitability | regulates | phenotype | 0.80 |
| orexin_receptor_1 | encodes | protein | 0.80 |
| Propofol | interacts_with | drug | 0.75 |
| Breast Carcinoma | therapeutic_target | disease | 0.75 |
| hemodynamic stability | regulates | phenotype | 0.75 |
| sleep-wake transition | associated_with | biological_process | 0.70 |
| neurodegeneration | associated_with | disease | 0.70 |
| HCRTR2 | interacts_with | gene | 0.70 |
| Sleep Disorder | therapeutic_target | disease | 0.65 |
| Sleep Disorder | regulates | disease | 0.65 |
| Addiction | associated_with | disease | 0.65 |
| Addiction | activates | disease | 0.65 |
| Ptsd | interacts_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Obesity | therapeutic_target | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| Depression | contributes_to | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Dementia | regulates | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Glioblastoma | expressed_in | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Depression | regulates | disease | 0.65 |
| Obesity | causes | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Orexinergic Neurons | expressed_in | cell_type | 0.92 |
| HCRT | co_mentioned_with | gene | 0.90 |
| NEURON | interacts_with | cell_type | 0.90 |
| h-9e9fee95 | targets_gene | hypothesis | 0.90 |
| h-9e9fee95 | targets | hypothesis | 0.80 |
| HCRTR2 | interacts_with | gene | 0.70 |
| HCRTR2 | regulates | gene | 0.60 |
| HCRTR2 | therapeutic_target | gene | 0.60 |
| PNOC | therapeutic_target | gene | 0.60 |
| TRPC6 | therapeutic_target | gene | 0.60 |
| HCRTR2 | associated_with | gene | 0.60 |
| DRD2 | activates | gene | 0.60 |
| HRH3 | activates | gene | 0.60 |
| HCRTR2 | activates | gene | 0.60 |
| ADRA1B | activates | gene | 0.60 |
| DRD1 | activates | gene | 0.60 |
| GRIA1 | activates | gene | 0.60 |
| ADRA1A | activates | gene | 0.60 |
| HRH1 | activates | gene | 0.60 |
| GRIN1 | activates | gene | 0.60 |
| BDNF | activates | entity | 0.60 |
| HCRT | interacts_with | gene | 0.60 |
| PNOC | associated_with | gene | 0.60 |
| HCRT | regulates | gene | 0.60 |
| GBM | inhibits | gene | 0.60 |
| LRRTM2 | expressed_in | gene | 0.60 |
| CPLX3 | inhibits | gene | 0.60 |
| HCRTR2 | expressed_in | gene | 0.60 |
| HCRT | activates | gene | 0.60 |
| ACE | associated_with | gene | 0.60 |
| HCRT | associated_with | gene | 0.60 |
| CHRM4 | expressed_in | gene | 0.60 |
| MYO7A | activates | gene | 0.60 |
| GRM2 | expressed_in | gene | 0.60 |
| WNT1 | activates | gene | 0.60 |
| CRH | expressed_in | gene | 0.60 |
| ADRA2B | expressed_in | gene | 0.60 |
| IL13 | activates | gene | 0.60 |
| CHRNE | expressed_in | gene | 0.60 |
| WNT11 | activates | gene | 0.60 |
| GRIN3B | expressed_in | gene | 0.60 |
| TNFRSF1B | activates | gene | 0.60 |
| TNFRSF13C | activates | gene | 0.60 |
| LRRTM2 | biomarker_for | gene | 0.60 |
| CD4 | expressed_in | gene | 0.60 |
| BRCA | expressed_in | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| GBM | activates | gene | 0.60 |
| CPLX3 | activates | gene | 0.60 |
| ACE | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||