concept

ALZHEIMER_DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALZHEIMER_DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

108Connections

1Hypotheses

13Analyses

11Outgoing

50Incoming

0Experiments

20Debates

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💡 Concept Info

Name	ALZHEIMER_DISEASE
Key Genes/Proteins	CYP46A1, EPILEPSY, GFAP
Related Diseases	ER_STRESS, INFLAMMATION, INSULIN_RESISTANCE, TYPE2_DIABETES
Related Pathways	COMPLEMENT

Pathway Diagram

graph TD
    ALZHEIMER_DISEASE["ALZHEIMER_DISEASE"]
    GADD45G["GADD45G"] -->|"activates"| ALZHEIMER_DISEASE
    CYP46A1["CYP46A1"] -->|"target for"| ALZHEIMER_DISEASE
    INFLAMMATION["INFLAMMATION"] -->|"contributes to"| ALZHEIMER_DISEASE
    ER_STRESS["ER_STRESS"] -->|"contributes to"| ALZHEIMER_DISEASE
    PHYTOCHEMICALS["PHYTOCHEMICALS"] -->|"treats"| ALZHEIMER_DISEASE
    APOE["APOE"] ---|"associated"| ALZHEIMER_DISEASE
    COMPLEMENT["COMPLEMENT"] ---|"associated"| ALZHEIMER_DISEASE
    TYROBP["TYROBP"] ---|"associated"| ALZHEIMER_DISEASE
    C1QC["C1QC"] ---|"associated"| ALZHEIMER_DISEASE
    CO9["CO9"] ---|"associated"| ALZHEIMER_DISEASE

Outgoing (11)

Target	Relation	Type	Str
memory loss	causes	unknown	0.95
neurodegeneration	contributes_to	disease	0.95
cognitive decline	causes	disease	0.95
neurodegeneration	associated_with	disease	0.90
neuroinflammation	associated_with	mechanism	0.90
oxidative_stress	associated_with	phenotype	0.85
microglial_activation	associated_with	mechanism	0.85
protein aggregation	associated_with	mechanism	0.85
protein_aggregation	involved_in	mechanism	0.80
mitochondrial_dysfunction	associated_with	mechanism	0.70
neuroinflammation	involved_in	mechanism	0.70

Incoming (97)

Source	Relation	Type	Str
tau_propagation	contributes_to	pathway	0.00
defective_efferocytosis	causes	phenotype	0.95
protein aggregation	associated_with	mechanism	0.95
mitochondrial_dysfunction	associated_with	mechanism	0.95
mitochondrial_dysfunction	involved_in	mechanism	0.95
NAD+ depletion	biomarker_for	mechanism	0.95
TREM2_protein	implicated_in	protein	0.95
APOE4	increases_risk	protein	0.95
neurovascular_dysfunction	associated_with	unknown	0.95
tau	biomarker_for	unknown	0.95
amyloid-β	biomarker_for	unknown	0.95
APOE4	biomarker_for	protein	0.95
microglial_activation	associated_with	mechanism	0.95
HSP70	modulates	protein	0.95
TREM2_protein	associated_with	protein	0.95
ageing	increases_risk	unknown	0.95
neurodegeneration	contributes_to	disease	0.95
interneuron dysfunction	implicated_in	unknown	0.95
Tau	involved_in	unknown	0.95
TREM1	contributes_to	unknown	0.95
TREM2_protein	increases_risk	protein	0.95
P-tau181	biomarker_for	unknown	0.95
network abnormalities	associated_with	unknown	0.95
brain aging	increases_risk	unknown	0.92
network hypersynchrony	contributes_to	unknown	0.90
ABCA7	increases_risk	unknown	0.90
ferroptosis	contributes_to	mechanism	0.90
HK2	implicated_in	protein	0.90
oxidative stress	associated_with	mechanism	0.90
microglial_activation	involved_in	mechanism	0.90
spatial_navigation	risk_factor_for	cognitive_function	0.90
APOE4	risk_factor_for	gene	0.90
poorly_lipidated_APOE	risk_factor_for	protein	0.90
protein aggregation	involved_in	mechanism	0.90
protein misfolding	contributes_to	unknown	0.90
mitochondrial_dysfunction	contributes_to	mechanism	0.90
glymphatic_clearance	involved_in	mechanism	0.90
glymphatic_clearance	associated_with	mechanism	0.90
cerebral_blood_flow_regulation	implicated_in	unknown	0.90
Semagacestat	causes	drug	0.90
phagocytosis	modulates	mechanism	0.90
necroptosis	implicated_in	unknown	0.90
glymphatic_clearance	contributes_to	mechanism	0.88
microglial_activation	contributes_to	mechanism	0.85
GCase	biomarker_for	protein	0.85
circadian disruption	associated_with	mechanism	0.85
Copper	associated_with	unknown	0.85
mitochondrial DNA release	biomarker_for	mechanism	0.85
neurodegeneration	associated_with	disease	0.85
AQP4	implicated_in	protein	0.85