Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALZHEIMER_DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ALZHEIMER_DISEASE |
| Key Genes/Proteins | GFAP, CYP46A1 |
| Related Diseases | INSULIN_RESISTANCE, TYPE2_DIABETES, INFLAMMATION, ER_STRESS |
| Related Pathways | COMPLEMENT |
Knowledge base pages for this entity
graph TD
ALZHEIMER_DISEASE["ALZHEIMER_DISEASE"]
GADD45G["GADD45G"] -->|"activates"| ALZHEIMER_DISEASE
CYP46A1["CYP46A1"] -->|"target for"| ALZHEIMER_DISEASE
INFLAMMATION["INFLAMMATION"] -->|"contributes to"| ALZHEIMER_DISEASE
ER_STRESS["ER_STRESS"] -->|"contributes to"| ALZHEIMER_DISEASE
PHYTOCHEMICALS["PHYTOCHEMICALS"] -->|"treats"| ALZHEIMER_DISEASE
APOE["APOE"] ---|"associated"| ALZHEIMER_DISEASE
COMPLEMENT["COMPLEMENT"] ---|"associated"| ALZHEIMER_DISEASE
TYROBP["TYROBP"] ---|"associated"| ALZHEIMER_DISEASE
C1QC["C1QC"] ---|"associated"| ALZHEIMER_DISEASE
CO9["CO9"] ---|"associated"| ALZHEIMER_DISEASE| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| INSULIN_RESISTANCE | implicated_in | phenotype | 0.80 |
| COMPLEMENT | associated_with | pathway | 0.64 |
| GFAP | associated_with | protein | 0.64 |
| TYPE2_DIABETES | associated_with | disease | 0.64 |
| CYP46A1 | therapeutic_target | gene | 0.60 |
| INFLAMMATION | contributes_to | phenotype | 0.56 |
| ER_STRESS | contributes_to | phenotype | 0.56 |
| PHYTOCHEMICALS | treats | drug | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neuroscience | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||