entity

lysosomal membrane permeabilization

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about lysosomal membrane permeabilization: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

3Hypotheses

2Analyses

7Outgoing

3Incoming

0Experiments

2Debates

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Outgoing (7)

Target	Relation	Type	Str
Cell Death	causes	phenotype	0.90
AUTOPHAGY	mediates	process	0.85
Autophagy	activates	process	0.85
PPP3	activates	protein	0.80
NLRP3 inflammasome activation	causes	mechanism	0.70
cellular dysfunction	causes	process	0.70
cell death	activates	process	0.70

Incoming (3)

Source	Relation	Type	Str
SPG20	involved_in	protein	0.95
Treahalose	associated_with	compound	0.90
Trehalose	associated_with	compound	0.90

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Galectin-3 deletion attenuates NLRP3 inflammasome activation	0.650	neuroscience	Lysosomal dysfunction and cathepsin leak
LAMP-2 replacement therapy prevents lysosomal membrane perme	0.580	neuroscience	Lysosomal dysfunction and cathepsin leak
Hsp70-based therapy to prevent lysosomal membrane permeabili	0.570	neuroscience	Lysosomal dysfunction and cathepsin leak

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does controlled lysosomal membrane permeabilization induce autophagy without

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.690

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.680

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

active · Rounds: 4 · Score: 0.76 · 2026-04-22

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

active · Rounds: 4 · Score: 0.61 · 2026-04-21