entity

lysosomal membrane permeabilization

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about lysosomal membrane permeabilization: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

3Hypotheses

5Analyses

10Outgoing

8Incoming

0Experiments

9Debates

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Outgoing (10)

Target	Relation	Type	Str
cathepsin B release	causes	process	0.90
Cell Death	causes	phenotype	0.90
Autophagy	activates	process	0.85
AUTOPHAGY	mediates	process	0.85
PPP3	activates	protein	0.80
cellular dysfunction	causes	process	0.70
cell death	activates	process	0.70
Cathepsin release	causes	process	0.70
NLRP3 inflammasome activation	causes	mechanism	0.70
tau seeds	associated_with	protein	0.70

Incoming (8)

Source	Relation	Type	Str
SPG20	involved_in	protein	0.95
Treahalose	associated_with	compound	0.90
Trehalose	associated_with	compound	0.90
trehalose	induces	drug	0.70
Ceramide accumulation	causes	process	0.70
trehalose	associated_with	drug	0.70
galectin-3	senses	protein	0.70
trehalose	causes	drug	0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Galectin-3 deletion attenuates NLRP3 inflammasome activation	0.625	neuroscience	Lysosomal dysfunction and cathepsin leak
LAMP-2 replacement therapy prevents lysosomal membrane perme	0.580	neuroscience	Lysosomal dysfunction and cathepsin leak
Hsp70-based therapy to prevent lysosomal membrane permeabili	0.570	neuroscience	Lysosomal dysfunction and cathepsin leak

Mentioning Analyses (5)

Scientific analyses that reference this entity

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-15 | 0 hypotheses

What determines the specificity of calcium-dependent PPP3/calcineurin activation

neurodegeneration | 2026-04-07 | 4 hypotheses Top: 0.705

How does controlled lysosomal membrane permeabilization induce autophagy without

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.690

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.679

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 22 hypotheses Top: 0.852

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (9)

Multi-agent debates referencing this entity

Extended debate: CYP46A1 Overexpression Gene Therapy

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Hypothesis debate: Membrane Cholesterol Gradient Modulators

closed · Rounds: 4 · Score: 0.50 · 2026-04-27

Hypothesis debate: Selective Acid Sphingomyelinase Modulation Therapy

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Hypothesis debate: CYP46A1 Overexpression Gene Therapy

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

While the study establishes that trehalose-induced lysosomal permeabilization ac

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

Does APOE4 drive tau propagation [TARGET_ARTIFACT type=hypothesis id=TEST-123]

closed · Rounds: 4 · Score: 0.64 · 2026-04-16

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

closed · Rounds: 5 · Score: 0.93 · 2026-04-11

Related Research

Hypotheses and analyses mentioning lysosomal membrane permeabilization in their description or question text

No additional research found