concept

TREHALOSE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREHALOSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

249Connections

2Hypotheses

9Analyses

50Outgoing

50Incoming

0Experiments

9Debates

Summary

TREHALOSE is a concept in neurodegeneration research. Key relationships include: activates, expressed in. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 98 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	TREHALOSE
Key Genes/Proteins	AKT, ALS, AMPK, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND
Related Diseases	AGING, Als, Amyotrophic Lateral Sclerosis, APOPTOSIS, Ataxia
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Trehalose for Neurodegenerative Diseases

therapeutic · 1790 words

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Pathway Diagram

graph TD
    TREHALOSE["TREHALOSE"]
    TREHALOSE -->|"activates"| TFEB["TFEB"]
    TREHALOSE -->|"activates"| autophagy["autophagy"]
    TREHALOSE -->|"treats"| multiple_sclerosis["multiple sclerosis"]
    TREHALOSE -->|"activates"| remyelination["remyelination"]
    TREHALOSE -->|"activates"| Atherosclerosis["Atherosclerosis"]
    TREHALOSE -->|"activates"| Huntington["Huntington"]
    TREHALOSE -->|"activates"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    TREHALOSE -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TREHALOSE -->|"activates"| Parkinson["Parkinson"]
    P62["P62"] -->|"activates"| TREHALOSE
    SOD1["SOD1"] -->|"activates"| TREHALOSE
    MAP1LC3B["MAP1LC3B"] -->|"activates"| TREHALOSE
    LGALS3["LGALS3"] -->|"activates"| TREHALOSE
    MCOLN1["MCOLN1"] -->|"activates"| TREHALOSE
    STIP1["STIP1"] -->|"activates"| TREHALOSE
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| TREHALOSE
    ALS["ALS"] -->|"activates"| TREHALOSE
    SQSTM1["SQSTM1"] -->|"activates"| TREHALOSE
    PPARGC1A["PPARGC1A"] -->|"activates"| TREHALOSE

Outgoing (182)

Target	Relation	Type	Str
Autophagy	activates	process	0.95
AUTOPHAGY	promotes	process	0.95
TFEB	activates	gene	0.95
TFEB	activates	gene	0.95
Autophagy	associated_with	process	0.95
lysosomal hydrolysis	resists	process	0.90
TFEB activation	activates	phenotype	0.90
Mtorc1	inhibits	protein	0.90
TFEB nuclear translocation	activates	process	0.90
V-ATPase	inhibits	protein	0.90
Lysosomal Membrane Permeabilization	associated_with	process	0.90
MTORC1 Inhibition	causes	phenotype	0.90
autophagy_pathway	activates	pathway	0.90
TFEB	activates	protein	0.90
autophagy	enhances	process	0.90
BBB	inhibits	brain_region	0.90
NEURODEGENERATION	protects_against	entity	0.85
LYSOSOME	modulates	entity	0.85
Motoneuron Degeneration	protects_against	disease	0.85
autophagy pathway	modulates	pathway	0.85
Autophagy-Related Genes	upregulates	gene	0.80
Neurodegenerative Diseases	associated_with	disease	0.80
Motoneuron Degeneration	treats	disease	0.80
TFEB	targets	gene	0.75
Autophagy	upregulates	process	0.75
ALS	treats	disease	0.75
Neurodegenerative Diseases	treats	disease	0.75
GDNF	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
TFEB	associated_with	protein	0.70
remyelination	activates	process	0.70
multiple sclerosis	treats	disease	0.70
Hsp70 expression	activates	process	0.70
apoptosis	prevents	process	0.70
tau pathology	reduces	phenotype	0.70
Lysosomal Membrane Permeabilization	associated_with	phenotype	0.70
lysosomal membrane permeabilization	causes	mechanism	0.70
tau pathology	reduces	phenotype	0.70
autophagy induction	causes (induces autophagy through multiple pathways includ)	mechanism	0.70
GDNF	protects_against	gene	0.70
lysosomal membrane permeabilization	induces	process	0.70
lysosomal swelling	causes	phenotype	0.70
intracellular cAMP	elevates	biomarker	0.70
autophagy	activates	process	0.70
FOXO3	activates	gene	0.70
TAU	activates	protein	0.70
Mtor	activates	pathway	0.70
Autophagy	activates	pathway	0.70
neurodegeneration	protective_against	disease	0.70
lysosomal biogenesis	activates	process	0.70

Incoming (67)

Source	Relation	Type	Str
TFEB	promotes	gene	0.65
NEURON	activates	cell_type	0.65
TFEB	inhibits	gene	0.65
TFEB	degrades	gene	0.65
NEURON	causes	cell_type	0.65
STIP1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ALS	activates	gene	0.60
SQSTM1	activates	gene	0.60
PPARGC1A	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
PARKINSON	activates	gene	0.60
STUB1	activates	gene	0.60
ATG	activates	gene	0.60
HSPB8	activates	gene	0.60
TREH	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ATG12	activates	gene	0.60
TARDBP	activates	gene	0.60
PPP3CB	activates	gene	0.60
CTSB	activates	gene	0.60
DNA	activates	gene	0.60
GENES	activates	gene	0.60
LAMP1	activates	gene	0.60
GAPDH	activates	gene	0.60
HSPA8	activates	gene	0.60
ATG10	activates	gene	0.60
GLA	activates	gene	0.60
MTOR	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
CALCINEURIN	activates	gene	0.60
BECN1	activates	gene	0.60
TFEB	activates	gene	0.60
LAMP2A	activates	gene	0.60
TPP1	activates	gene	0.60
PPP3	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
BCL2	activates	gene	0.60
BAG3	activates	gene	0.60
MTORC1	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
RNA	activates	gene	0.60
SOD1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
LGALS3	activates	gene	0.60
MCOLN1	activates	gene	0.60
P62	activates	gene	0.60
AND	activates	gene	0.60
PROTEIN CLEARANCE	associated_with	phenotype	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cell-Type-Specific TFEB Modulation Combined with Trehalose f	0.000	proteomics	Quantitative proteomics of the aging syn
Trehalose-Resistant Autophagy Bypass Pathway	0.000	-	How do non-cell autonomous effects of au

Mentioning Analyses (9)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (9)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning TREHALOSE in their description or question text

No additional research found

TREHALOSE

Understanding Entity Pages

Summary

Wiki Pages (1)

Trehalose for Neurodegenerative Diseases

Pathway Diagram

Outgoing (182)

Incoming (67)

Targeting Hypotheses (2)

Mentioning Analyses (9)

Microglial senescence in Alzheimer and Parkinson disease progression

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

Do tau strains or regional cellular environments primarily drive PSP vs CBD path

Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce ide

What determines the specificity of calcium-dependent PPP3/calcineurin activation

How does controlled lysosomal membrane permeabilization induce autophagy without

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

Experiments (0)

Related Papers (0)

Debates (9)

Microglial senescence in Alzheimer and Parkinson disease progression

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

While the study establishes that trehalose-induced lysosomal permeabilization ac

The finding that trehalase-resistant analogs and other disaccharides mimic treha

The core debate question remains unresolved - whether intrinsic tau conformation

How does synaptic protein turnover change with age and neurodegeneration, and wh

The study shows PSEN2 is essential in cortical and dopaminergic neurons and regu

The debate highlighted TFEB's role in mitochondrial-lysosomal coupling but could

Related Research