concept

CELL DEATH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELL DEATH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

534Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CELL DEATH is a concept in neurodegeneration research. Key relationships include: co discussed, causes, activates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 129 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CELL DEATH
Key Genes/Proteins	GPX4, PARP1, TDP-43, ATM, PARKIN, UBIQUITIN
Related Diseases	CYTOKINES, ISCHEMIA, ER STRESS, ROS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CELL_DEATH["<b>CELL DEATH</b>"]
    CELL_DEATH -->|"inhibits"| PARP1["PARP1"]
    CELL_DEATH -->|"inhibits"| T_CELL["T CELL"]
    CELL_DEATH -->|"inhibits"| T_CELLS["T CELLS"]
    CELL_DEATH -->|"causes"| INFLAMMATION["INFLAMMATION"]
    CELL_DEATH -->|"regulates"| FERROPTOSIS["FERROPTOSIS"]
    CELL_DEATH -->|"regulates"| GPX4["GPX4"]
    CELL_DEATH -->|"causes"| TNF["TNF"]
    CELL_DEATH -->|"contributes to"| NECROPTOSIS["NECROPTOSIS"]
    CELL_DEATH -->|"contributes to"| PYROPTOSIS["PYROPTOSIS"]
    CASPASES["CASPASES"] -->|"mediates"| CELL_DEATH
    Ferroptosis["Ferroptosis"] -->|"causes"| CELL_DEATH
    AMPK["AMPK"] -->|"regulates"| CELL_DEATH
    ER_stress["ER stress"] -->|"causes"| CELL_DEATH
    excessive_mitophagy["excessive mitophagy"] -->|"causes"| CELL_DEATH
    RIPK1["RIPK1"] -->|"mediates"| CELL_DEATH
    Metabolism["Metabolism"] -->|"modulates"| CELL_DEATH
    Autophagy["Autophagy"] -.protects against.-> CELL_DEATH
    DRAGO["DRAGO"] -->|"causes"| CELL_DEATH
    autophagy["autophagy"] -.protects against.-> CELL_DEATH
    DNA_Damage_Response["DNA Damage Response"] -->|"interacts"| CELL_DEATH
    NPM["NPM"] -->|"regulates"| CELL_DEATH

Outgoing (122)

Target	Relation	Type	Str
GPX4	causes	gene	0.70
CYTOKINES	inhibits	phenotype	0.70
CYTOKINES	regulates	phenotype	0.70
GLUTAMATE	causes	phenotype	0.65
NEURODEGENERATION	treats	phenotype	0.65
INFLAMMATION	treats	phenotype	0.65
CANCER	confers_resistance	disease	0.65
IRON ACCUMULATION	causes	phenotype	0.65
LIPID PEROXIDATION	causes	phenotype	0.65
DRUG RESISTANCE	treats	phenotype	0.65
DRP1	phosphorylates	gene	0.65
P38	phosphorylates	gene	0.65
P38	activates	gene	0.65
LIPID PEROXIDATION	activates	phenotype	0.65
LIPID PEROXIDATION	regulates	phenotype	0.65
LYMPHOMA	inhibits	disease	0.65
IMMUNE RESPONSE	activates	phenotype	0.65
FERROPTOSIS	targets	phenotype	0.60
MICROGLIAL ACTIVATION	converts	phenotype	0.60
NEURODEGENERATION	implicated_in	phenotype	0.55
NEUROINFLAMMATION	implicated_in	phenotype	0.55
ALZHEIMER'S DISEASE	implicated_in	disease	0.55
ALZHEIMER'S DISEASE	participates_in	disease	0.55
NECROPTOSIS	implicated_in	phenotype	0.55
Infection	causes	disease	0.50
GPX4/SLC7A11	inhibits	concept	0.50
CARDIOMYOCYTES	regulates	concept	0.50
HEPATOCYTES	activates	concept	0.50
HEPATOCYTES	associated_with	concept	0.50
Infection	activates	disease	0.50
Pancreatic Cancer	activates	disease	0.50
DNA DAMAGE	activates	concept	0.50
Dna Damage Response	activates	pathway	0.50
Reactive Oxygen Species	activates	process	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
CX43	causes	concept	0.50
GLUTAMATE	inhibits	concept	0.50
BREAST CANCER	activates	disease	0.50
Drug Resistance	activates	pathway	0.50
T CELLS	activates	concept	0.50
Immune Checkpoint	activates	pathway	0.50
Proteins	causes	protein	0.50
SPINAL CORD INJURY	causes	concept	0.50
Fatty Liver	activates	disease	0.50
NAFLD	activates	disease	0.50
GENE EXPRESSION	activates	concept	0.50
ORGANOIDS	activates	concept	0.50
Drug Resistance	inhibits	pathway	0.50
PD-L1	inhibits	concept	0.50
GLUTAMATE	regulates	concept	0.50

Incoming (412)

Source	Relation	Type	Str
BAX	mediates	entity	0.90
MTOR	regulates	entity	0.85
ISCHEMIA	inhibits	disease	0.70
PARP1	causes	gene	0.70
MACROPHAGE	activates	cell_type	0.70
TDP-43	inhibits	gene	0.70
TDP-43	causes	gene	0.70
ATM	regulates	gene	0.70
ER STRESS	activates	phenotype	0.70
PARKIN	modifies	gene	0.70
UBIQUITIN	activates	protein	0.70
ROS	inhibits	phenotype	0.70
MONOCYTES	activates	cell_type	0.70
EXCITOTOXICITY	activates	phenotype	0.70
EXOSOME	regulates	organelle	0.70
HDAC3	treats	gene	0.70
HDAC3	activates	gene	0.70
HDAC3	inhibits	gene	0.70
SIRT3	regulates	gene	0.70
MICROGLIAL ACTIVATION	biomarker_for	phenotype	0.70
MICROGLIAL ACTIVATION	regulates	phenotype	0.70
T CELLS	targets	cell_type	0.65
FERROPTOSIS	protects_against	phenotype	0.65
MTOR PATHWAY	activates	pathway	0.65
CURCUMIN	inhibits	drug	0.65
METFORMIN	treats	drug	0.65
NICOTINAMIDE	produces	drug	0.65
LEWY BODIES	produces	phenotype	0.65
OXIDATIVE STRESS	produces	phenotype	0.65
TH	activates	gene	0.65
LACTATE	biomarker_for	phenotype	0.65
LACTATE	produces	phenotype	0.65
LRRK2	exacerbates	gene	0.65
OXIDATIVE STRESS	protects_against	phenotype	0.65
CELL PROLIFERATION	inhibits	phenotype	0.65
AXONAL TRANSPORT	causes	phenotype	0.65
MITOPHAGY	interacts_with	phenotype	0.65
RIBOSOME	activates	organelle	0.65
MITOCHONDRIAL DYSFUNCTION	inhibits	phenotype	0.65
TUMOR CELLS	causes	cell_type	0.65
GPX4	treats	gene	0.65
NEURONS	synergizes_with	cell_type	0.60
FERROPTOSIS	converts	phenotype	0.60
FERROPTOSIS	destabilizes	phenotype	0.60
NEURONS	produces	cell_type	0.60
AUTOPHAGY	implicated_in	phenotype	0.55
FERROPTOSIS	implicated_in	phenotype	0.55
APOPTOSIS	implicated_in	phenotype	0.55
CGAS	implicated_in	gene	0.55
PARP1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CELL DEATH

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Parthanatos in Neurodegeneration

Alpha-Synuclein Pathology

Corticobasal Degeneration (CBD)

nimodipine-als

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

GRIA3 Gene

NTF4 Protein

TREM2 Mechanism Hub

Growth Factor Therapies

Mitochondrial Dysfunction in Parkinson's Disease

Synucleinopathy Mechanism

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms