Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about myelin dysfunction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Amyloid-Beta Deposition | causes | process | 0.95 |
| memory impairment | causes | phenotype | 0.70 |
| amyloid-beta accumulation | causes | phenotype | 0.50 |
| glymphatic clearance impairment | causes | mechanism | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| OPC epigenetic drift | causes | process | 0.70 |
| oligodendrocytes | involved_in | cell_type | 0.60 |
| cortex | exhibits | brain_region | 0.60 |
| PLP1 | associated_with | gene | 0.55 |
| ELF2 downregulation | causes | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ELF2-Mediated OPC Epigenetic Drift Drives Region-Dependent M | 0.508 | alzheimer | Allen Mouse Brain Aging Atlas: cross-age |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-23 | 8 hypotheses Top: 0.519
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Early disease phase characterized by remyelination response from oligo | cell_biology | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Prevalent mesenchymal drift in aging and disease is reversed by partial reprogra [PMID:40816266] | Lu JY, Tu WB, Li R | Cell | 2025 | 0 |
| The neuropathobiology of multiple sclerosis. [PMID:38789516] | Woo MS, Engler JB, Friese MA | Nat Rev Neurosci | 2024 | 0 |
| Innate immune memory after brain injury drives inflammatory cardiac dysfunction. [PMID:39043180] | Simats A, Zhang S, Messerer D | Cell | 2024 | 0 |
| The neuropathobiology of multiple sclerosis. [PMID:38789516] | Woo MS, Engler JB, Friese MA | Nature reviews. Neuroscience | 2024 | 0 |
| Innate immune memory after brain injury drives inflammatory cardiac dysfunction. [PMID:39043180] | Simats A, Zhang S, Messerer D, Chong F, | Cell | 2024 | 0 |
| Epigenomic dissection of Alzheimer's disease pinpoints causal variants and revea [PMID:37774680] | Unknown | Cell | 2023 | 0 |
| Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. [PMID:37258678] | Depp C, Sun T, Sasmita AO | Nature | 2023 | 0 |
| Epigenomic dissection of Alzheimer's disease pinpoints causal variants and revea [PMID:37774680] | Xiong, James, Boix, Park, Galani et al. | Cell | 2023 | 0 |
| Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to path [PMID:37964328] | Zou P, Wu C, Liu TC, Duan R, Yang L | Translational neurodegeneratio | 2023 | 0 |
| Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. [PMID:37258678] | Depp C, Sun T, Sasmita AO, Spieth L, Ber | Nature | 2023 | 0 |
| Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to path [PMID:37964328] | Zou P, Wu C, Liu TC, Duan R, Yang L | Translational neurodegeneratio | 2023 | 0 |
| Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell [PMID:30936558] | Unknown | Nature neuroscience | 2019 | 0 |
| Oligodendrocytes in Development, Myelin Generation and Beyond. [PMID:31726662] | ["Kuhn Sarah", "Gritti Laura", "Crooks D | Cells | 2019 | 0 |
| Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell [PMID:30936558] | Unknown | Nature neuroscience | 2019 | 0 |
| Oligodendrocytes in Development, Myelin Generation and Beyond. [PMID:31726662] | ["Kuhn Sarah", "Gritti Laura", "Crooks D | Cells | 2019 | 0 |
| Endothelial Cell Metabolism. [PMID:29167330] | Eelen G, de Zeeuw P, Treps L | Physiol Rev | 2018 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | Iacozza Sara; Costa Albert; Duñabei | PloS one | 2017 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | ["Iacozza, Sara", "Costa, Albert", "Du\u | PloS one | 2017 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning myelin dysfunction in their description or question text
No additional research found