PLP1

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PLP1 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Als, Alzheimer. Connected to 47 entities in the SciDEX knowledge graph.

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graph TD
    PLP1["<b>PLP1</b>"]
    Pelizaeus_Merzbacher_disease{"Pelizaeus-Merzbacher disease"}
    PLP1 -->|"causes"| Pelizaeus_Merzbacher_disease
    Dementia{"Dementia"}
    PLP1 -->|"activates"| Dementia
    Als{"Als"}
    PLP1 -->|"activates"| Als
    Alzheimer{"Alzheimer"}
    PLP1 -->|"activates"| Alzheimer
    Parkinson{"Parkinson"}
    PLP1 -->|"activates"| Parkinson
    Ms{"Ms"}
    PLP1 -->|"activates"| Ms
    ALS{"ALS"}
    PLP1 -->|"activates"| ALS
    Phagocytosis(["Phagocytosis"])
    PLP1 -->|"activates"| Phagocytosis
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    PLP1 -->|"activates"| ALZHEIMER_S_DISEASE
    MBP["MBP"]
    PLP1 -->|"activates"| MBP
    HSPA1A["HSPA1A"]
    PLP1 -->|"activates"| HSPA1A
    MSR1["MSR1"]
    PLP1 -->|"activates"| MSR1
    MBP -->|"associated with"| PLP1
    MOG["MOG"]
    MOG -->|"associated with"| PLP1
    MYELIN["MYELIN"]
    MYELIN -->|"associated with"| PLP1
    OLIGODENDROCYTE["OLIGODENDROCYTE"]
    OLIGODENDROCYTE -->|"associated with"| PLP1
    HSPA1A -->|"activates"| PLP1
    MBP -->|"activates"| PLP1
    MSR1 -->|"activates"| PLP1
    GENES["GENES"]
    GENES -->|"activates"| PLP1
    MBP -->|"co discussed"| PLP1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"co discussed"| PLP1
    MYELIN -->|"co discussed"| PLP1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| PLP1
    style PLP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0