cellular_component

cortex

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about cortex: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1843Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

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AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Pathway Diagram

graph TD
    neuroinflammation["neuroinflammation"] -->|"affects"| cortex["cortex"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    DNA["DNA"] -->|"expressed in"| cortex["cortex"]
    style DNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BDNF["BDNF"] -->|"expressed in"| cortex["cortex"]
    style BDNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"expressed in"| cortex["cortex"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"expressed in"| cortex["cortex"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style cortex fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (669)

Target	Relation	Type	Str
STRIATUM	expressed_in	brain_region	0.95
NEURON	activates	cell_type	0.95
HIPPOCAMPUS	regulates	brain_region	0.95
STEM CELLS	activates	cell_type	0.95
HIPPOCAMPUS	activates	brain_region	0.95
EPILEPSY	interacts_with	disease	0.95
INTERNEURONS	expressed_in	cell_type	0.95
NEURON	interacts_with	cell_type	0.95
HIPPOCAMPUS	inhibits	brain_region	0.95
PARVALBUMIN INTERNEURONS	expressed_in	entity	0.85
NEURON	implicated_in	cell_type	0.80
SYNAPTIC LOSS	causes	phenotype	0.70
SYNAPTIC LOSS	regulates	phenotype	0.70
ALS	treats	disease	0.70
ASTROCYTE	causes	cell_type	0.70
CA1	causes	brain_region	0.70
FUS	regulates	gene	0.65
SOD1	regulates	gene	0.65
SPINAL CORD	expressed_in	brain_region	0.65
HIPPOCAMPUS	accumulates_in	brain_region	0.65
WHITE MATTER	reduces	brain_region	0.65
ENTORHINAL	associated_with	brain_region	0.65
FRONTAL	associated_with	brain_region	0.65
HIPPOCAMPUS	expressed_in	brain_region	0.65
HIPPOCAMPUS	contributes_to	brain_region	0.65
MOTOR NEURON	causes	cell_type	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
PYRAMIDAL	reduces	cell_type	0.65
GFAP	sensitizes_to	gene	0.65
GABAERGIC	targets	cell_type	0.65
INTERNEURON	targets	cell_type	0.65
INTERNEURONS	targets	cell_type	0.65
FRONTAL	regulates	brain_region	0.65
PREFRONTAL	regulates	brain_region	0.65
SPINAL CORD	accumulates_in	brain_region	0.65
GLUTAMATERGIC	activates	cell_type	0.65
TUMOR	activates	disease	0.65
IPSC	activates	cell_type	0.65
GRAY MATTER	expressed_in	brain_region	0.65
MTOR	activates	gene	0.65
SCHIZOPHRENIA	regulates	disease	0.65
FRONTOTEMPORAL DEMENTIA	activates	disease	0.65
THALAMUS	expressed_in	brain_region	0.65
NEURODEGENERATION	regulates	process	0.65
EPILEPSY	expressed_in	disease	0.65
PREFRONTAL CORTEX	impairs	brain_region	0.65
TAU	phosphorylates	gene	0.65
PREFRONTAL CORTEX	contributes_to	brain_region	0.65
PREFRONTAL CORTEX	transports	brain_region	0.65

Incoming (1174)

Source	Relation	Type	Str
neuroinflammation	affects	disease	0.90
DNA	expressed_in	gene	0.90
BDNF	expressed_in	gene	0.90
ALS	expressed_in	gene	0.90
ALS	affects	disease	0.90
RNA	expressed_in	gene	0.90
epilepsy	affects	disease	0.90
GFAP	expressed_in	gene	0.90
Alzheimer's disease	affects	disease	0.90
frontotemporal dementia	affects	disease	0.90
traumatic brain injury	affects	disease	0.90
aging	affects	disease	0.90
schizophrenia	affects	disease	0.90
depression	affects	disease	0.90
unfolded protein response	active_in	pathway	0.90
APP	expressed_in	gene	0.90
neurodegeneration	affects	disease	0.90
SST	expressed_in	gene	0.90
AQP4	expressed_in	gene	0.80
CREB	expressed_in	gene	0.80
TNF	expressed_in	gene	0.80
PI3K-AKT-mTOR signaling	active_in	pathway	0.80
anxiety	affects	disease	0.80
autism	affects	disease	0.80
AMPK	expressed_in	gene	0.80
APOE	expressed_in	gene	0.80
FUS	expressed_in	gene	0.80
MAPT	expressed_in	gene	0.80
GABA	expressed_in	gene	0.80
HDAC3	expressed_in	gene	0.80
NMDA receptor	expressed_in	receptor	0.80
nicotinic receptor	expressed_in	receptor	0.80
dopamine receptor	expressed_in	receptor	0.80
epigenetic regulation	active_in	pathway	0.70
Parkinson's disease	affects	disease	0.70
synaptic plasticity	active_in	pathway	0.70
CRH	expressed_in	gene	0.70
glutamate signaling	active_in	pathway	0.70
STING	expressed_in	gene	0.70
lipid metabolism	active_in	pathway	0.70
multiple sclerosis	affects	disease	0.70
PVALB	expressed_in	gene	0.70
glioblastoma	affects	disease	0.70
SYNCRIP	expressed_in	gene	0.70
CHRNA7	expressed_in	gene	0.70
NR3C1	expressed_in	gene	0.70
complement cascade	active_in	pathway	0.70
HDAC	expressed_in	gene	0.70
TREM2	expressed_in	gene	0.70
NLRP3	expressed_in	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (3)

Scientific analyses that reference this entity

Entorhinal cortex layer II vulnerability in Alzheimer's disease

neurodegeneration | 2026-04-02 | 0 hypotheses

Selective vulnerability of entorhinal cortex layer II neurons in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.484

Selective vulnerability of entorhinal cortex layer II neurons in AD

neurodegeneration | 2026-04-01 | 0 hypotheses

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025
Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373]	Fisher J, Verhagen M, Long Z, Moissidis	Neuron	2024
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473]	Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a	Adv Sci (Weinh)	2024
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024
Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213]	Mòdol L, Moissidis M, Selten M, Oozeer F	Neuron	2024
De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258]	Tang S, Conte V, Zhang DJ, Žedaveinytė R	Science	2024
Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868]	Xia D, Lianoglou S, Sandmann T, Calvert	Mol Neurodegener	2022
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149]	Fogaça MV, Wu M, Li C, Li XY, Picciotto	Mol Psychiatry	2021
Identification of Faecalibacterium prausnitzii strains for gut microbiome-based [PMID:34622235]	Ueda A, Shinkai S, Shiroma H, Taniguchi	Cell Rep Med	2021
Somatostatin, Olfaction, and Neurodegeneration. [PMID:32140092]	Saiz-Sanchez D, Ubeda-Bañon I, Flores-Cu	Front Neurosci	2020
Somatostatin replacement: a new strategy for treating diabetic retinopathy. [PMID:23745546]	Hernández C, Simó R, European Consortium	Curr Med Chem	2013

cortex

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

NPM1 Gene

PI-2620 Tau PET in PSP

Neurons — Cell Type Hierarchy

Pathway Diagram

Outgoing (669)

Incoming (1174)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Entorhinal cortex layer II vulnerability in Alzheimer's disease

Selective vulnerability of entorhinal cortex layer II neurons in AD

Selective vulnerability of entorhinal cortex layer II neurons in AD

Related Papers (12)