gene

TFEC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TFEC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TFEC (Transcription Factor EC) - lysosomal-autophagy transcription factor in microglia, part of MITF/TFEB/TFE3/TFEC family, relevant to AD/PD through TREM2 crosstalk

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🧬 Gene Info

Gene Symbol	TFEC
Full Name	Transcription Factor EC
Chromosome	6p21.1
Protein Family	bHLH-Zip (MITF/TFEB/TFE3/TFEC)
Function	Lysosomal biogenesis, autophagy regulation
Primary Expression	Microglia, brain macrophages
Pathways	pathway: ```mermaid, mTOR
GeneCards	TFEC
Human Protein Atlas	TFEC
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TFEC Gene

gene · 652 words

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TFEC Gene

gene · 727 words

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Pathway Diagram

graph TD
    TFEC["TFEC"]
    neurodegeneration["neurodegeneration"]
    TFEC -->|"implicated_in"| neurodegeneration
    style TFEC fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity