🧫
Plasma ATN biomarkers across AD continuum in Chilean cohort
active
experiment
Created: 2026-04-11T00:47:52
By: experiment_extractor
Quality:
95%
✓ SciDEX
ID: experiment-exp-4e93cf83-f629-4415-8d21-6
🧫 Experiment Protocol
Clinicalproposed
N = 318
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-11T00:47:52.746753'} |
| p_value | None |
| protocol | Plasma ATN biomarkers (Aβ42/Aβ40, p-tau217, NfL, GFAP) quantified using Simoa technology; cognitive assessment with ACE, FCSRT, T-ADLQ; ANCOVA models adjusted for age, sex, education; linear regressio |
| effect_size | AUC = 0.88 for p-tau217 distinguishing ADD from CU |
| sample_size | 318 |
| source_pmid | 41691306 |
| extracted_at | 2026-04-10T17:47:52.742402 |
| _schema_version | 1 |
| experiment_type | clinical |
| success_criteria | Significant group differences in biomarker levels; high diagnostic accuracy for distinguishing disease stages |
| expected_outcomes | Progressive decline in Aβ42/Aβ40 ratio and elevations in p-tau217 and GFAP across clinical continuum; inverse associations between p-tau217/NfL and cognitive performance |
| statistical_methods | ANCOVA models adjusted for age, sex, education; linear regression analyses; supervised machine learning with cross-validation |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
56
Outgoing
57
0 supporting
0 contradicting
0 neutral
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