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Can pathological vs physiological C1q tagging be distinguished at the molecular level?

PARTIALLY ADDRESSED

The debate revealed a fundamental gap: whether disease-specific C1q conformational changes or co-localization patterns exist that could enable selective therapeutic targeting. This selectivity problem was identified as 'unsolvable with current technology' but remains critical for complement-based therapies. Source: Debate session sess_sda-2026-04-01-gap-v2-691b42f1 (Analysis: sda-2026-04-01-gap-v2-691b42f1)

Priority: 0.90 Domain: neurodegeneration Hypotheses: 0
📊 Landscape Analysis

Landscape Summary: Can pathological vs physiological C1q tagging be distinguished at the molecular level? is a 0.9 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

Can pathological vs physiological C1q tagging be distinguished at the molecular level? — INVOKE-2 (completed)

📈 Living Dashboards
0
Hypotheses
0.000
Top Score
0.000
Avg Score
0
Debates
0.00
Avg Quality
60%
Resolution
0
Mechanistic Families
Gap Resolution Progress60%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)

No hypotheses linked to this gap yet.

🌊 Knowledge Graph Connections

activates (18)

C1q→Microglial PhagocytosisC1q→microglial CR3 engagementC1q→Microglia-Mediated Synapse LossC1q→A1 reactive astrocytesC1q→Classical Complement Cascade
▸ Show 13 more

associated with (8)

C1q→Complement activationC1q→vulnerable synapses in ADC1q→complement-dependent phagocytosisC1q→lipid raftsCRP→C1q
▸ Show 3 more

causes (5)

C1q→SYNAPSE_ELIMINATIONC1q→synaptic dysfunctionC1q→immunosuppressionC1q→synaptic_lossC1q→tumor cell survival

contributes to (1)

STAT6-MafB pathway→C1q

enhances (1)

C1q→pro-tumor inflammation

increases risk (1)

C1q→Alzheimer's_disease

inhibits (2)

TYROBP deficiency→C1qC1q→Aβ fibril formation

interact with (1)

33628204→C1q

involved in (1)

C1q→Synaptic Pruning

mediates (4)

C1q→Synaptic TaggingC1q→synaptic pruningC1q→Microglial Synaptic EliminationC1q→antibody-antigen complex recognition

produces (2)

tumor-associated macrophages→C1qmicroglia→C1q

regulates (4)

C1q→gC1qRC1q→synaptic stabilityC1q→pruning of stressed neuronsC1q→M2 macrophage polarization

upregulates (2)

ABETA→C1qC1q→Glaucoma
🕑 Activity Feed
✏ update on knowledge_gap by max_gmail 2026-04-26T18:31
✏ update on knowledge_gap by None 2026-04-25T22:15
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