APOE should remain under review until replicated

graph TD
    APOE4["APOE4"] -->|causes| lipid_dysregulation["lipid dysregulation"]
    APOE4_1["APOE4"] -->|causes| synaptic_phagocytosis["synaptic phagocytosis"]
    APOE4_2["APOE4"] -->|risk factor for| AD["AD"]
    lipid_dysregulation_3["lipid dysregulation"] -->|drives| AD_pathology["AD pathology"]
    synaptic_phagocytosis_4["synaptic phagocytosis"] -->|drives| AD_pathology_5["AD pathology"]
    APOE4_to_APOE3_correction["APOE4 to APOE3 correction"] -->|prevents| amyloid["amyloid"]
    APOE4_to_APOE3_correction_6["APOE4 to APOE3 correction"] -->|modulates| synaptic_function["synaptic function"]
    APOE_genotype["APOE genotype"] -->|associated with| AD_7["AD"]
    neuron_microglia_astrocyt["neuron-microglia-astrocyte co-culture validation"] -->|regulates| APOE4_synaptic_causality["APOE4 synaptic causality"]
    APOE4_8["APOE4"] -->|causes| amyloid_9["amyloid"]
    amyloid_10["amyloid"] -->|biomarker for| AD_11["AD"]
    microglia["microglia"] -->|regulates| synaptic_phagocytosis_12["synaptic phagocytosis"]
    style APOE4 fill:#ce93d8,stroke:#333,color:#000
    style lipid_dysregulation fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_1 fill:#ce93d8,stroke:#333,color:#000
    style synaptic_phagocytosis fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_2 fill:#ce93d8,stroke:#333,color:#000
    style AD fill:#ef5350,stroke:#333,color:#000
    style lipid_dysregulation_3 fill:#4fc3f7,stroke:#333,color:#000
    style AD_pathology fill:#4fc3f7,stroke:#333,color:#000
    style synaptic_phagocytosis_4 fill:#4fc3f7,stroke:#333,color:#000
    style AD_pathology_5 fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_to_APOE3_correction fill:#4fc3f7,stroke:#333,color:#000
    style amyloid fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_to_APOE3_correction_6 fill:#4fc3f7,stroke:#333,color:#000
    style synaptic_function fill:#4fc3f7,stroke:#333,color:#000
    style APOE_genotype fill:#ce93d8,stroke:#333,color:#000
    style AD_7 fill:#ef5350,stroke:#333,color:#000
    style neuron_microglia_astrocyt fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_synaptic_causality fill:#4fc3f7,stroke:#333,color:#000
    style APOE4_8 fill:#ce93d8,stroke:#333,color:#000
    style amyloid_9 fill:#4fc3f7,stroke:#333,color:#000
    style amyloid_10 fill:#4fc3f7,stroke:#333,color:#000
    style AD_11 fill:#ef5350,stroke:#333,color:#000
    style microglia fill:#4fc3f7,stroke:#333,color:#000
    style synaptic_phagocytosis_12 fill:#4fc3f7,stroke:#333,color:#000