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Food-grade TiO2/TDCPP Co-exposure disrupts ACOD1/itaconate axis and is associated with TET2-NF-κB inflammation in microglia exacerbating neurotoxicity.
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Food-grade TiO2/TDCPP Co-exposure disrupts ACOD1/itaconate axis and is associated with TET2-NF-κB inflammation in microglia exacerbating neurotoxicity.
Guo Q, Wang D, Zhao C, Wei S, Hu C, Liu Z, Li Y, Li R, Wang J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
PubMed
DOI
Abstract
Food-grade titanium dioxide (TiO2) and tris (1, 3-dichloro-2-propyl) phosphate (TDCPP) are environmental pollutants with high exposure among children, which pose potential risks to neurodevelopment. However, the neurotoxicity of their co-exposure remains poorly understood. In this study, we employed C8-D1A astrocytes, BV2 microglia, and Neuro-2a neuroblastoma cells to investigate the neurotoxicity of food-grade TiO2 and TDCPP co-exposure. Toxicity experiments revealed that combined exposure to f...
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