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TET1 deficiency amplifies macrophage inflammatory signaling associated with Crohn's disease.
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ID: paper-41896302
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TET1 deficiency amplifies macrophage inflammatory signaling associated with Crohn's disease.
["Perez R", "Paul R", "Kumar P", "Tutkun A", "Webb D", "McGorty S", "Wieckowski T", "Yap Y", "Leesang T", "Vlantis P"]
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
PubMed
DOI
Abstract
OBJECTIVE AND DESIGN: To define the role of Ten-Eleven Translocation (TET) proteins in Crohn's disease (CD)-associated inflammation through integrative human and mechanistic studies. MATERIAL: Publicly available CD transcriptomic and DNA methylation datasets, and primary mononuclear cells and ileal biopsies were analyzed for TET gene expression and signatures. TET1 and TET2 CRISPR/Cas9 knockout macrophage cell lines were generated. TREATMENT: Macrophages were stimulated with LPS in the presence ...
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