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Figure 1 — Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt
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Created: 2026-04-21T18:29:40
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Figure 1Figure 1
Neutrophils infiltrating and extruding extracellular traps (NETosis) in NMO mouse spinal cord. ( A ) Experimental design: catheter inserted via cisterna magna into L4 subarachnoid space (yellow circle, Evans blue verification). Subcutaneous osmotic pump continuously infuses AQP4-IgG or control mouse IgG (1.2 μg/d, in 12 μL). Rotarod motor training, days –3, –2, –1; testing, days 0, +1, +2, +3, +4, and +5. Terminal transcardiac perfusion: cord harvested for immunohistochemical and flow cytometric analyses. ( B ) Cord-infiltrating neutrophils (Cytek analysis), IgG infusion days 1, 3, and 5. Control mice (first panel) infused 3 days with normal mouse IgG. AQP4-IgG recipients: panels 2–4 (3 mice/group). t-SNE, t-distributed stochastic neighbor embedding. ( C – E ) IgG infusion day 3: representative images ( C and D ) and quantification ( E ) of neutrophils (Ly6G + MPO + ) in lumbar parenchyma (4 mice/group). Higher magnification box in C shows neutrophils (magenta) and nuclei (blue). (
▸Metadata
| pmid | paper-41665955 |
| caption | Neutrophils infiltrating and extruding extracellular traps (NETosis) in NMO mouse spinal cord. ( A ) Experimental design: catheter inserted via cisterna magna into L4 subarachnoid space (yellow circle |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13038209/bin/jci-136-199706-g001.jpg |
| paper_title | Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis optica model induced by subarachnoid AQP4-IgG. |
| figure_label | Figure 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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