| sess_SDA-2026-04-10- | The debate highlighted a critical cell-type specificity gap where no evidence ex | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095945-976d542d |
| sess_SDA-2026-04-10- | The debate presented conflicting evidence for convergent vs. stimulus-specific c | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095952-12fad421 |
| sess_SDA-2026-04-10- | The debate hinged on whether HSP90 adopts unique conformations when bound to tau | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-095958-ccbb9a80 |
| sess_SDA-2026-04-10- | This fundamental question underlies all therapeutic hypotheses but lacks experim | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100007-6c187cfd |
| sess_SDA-2026-04-10- | The core research question was never addressed due to missing literature content | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100352-6c86d947 |
| sess_SDA-2026-04-10- | The debate was structured around this question but no literature was provided to | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100357-76f5b31e |
| sess_SDA-2026-04-10- | The debate identified a critical gap in understanding whether PS exposure is tau | 0.44 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100359-5f096b45 |
| sess_SDA-2026-04-10- | The debate revealed a fundamental gap in understanding whether tau pathology dir | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-100403-c213d072 |
| sess_SDA-2026-04-11- | The debate proposed biphasic TREM2 modulation but couldn't define when to switch | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-100405-abac24bc |
| sess_SDA-2026-04-11- | The debate proposed temporal TREM2 modulation but couldn't define when to switch | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-100409-e0118210 |
| sess_SDA-2026-04-11- | The debate identified this as a critical mechanistic gap - TFEB may increase lys | 0.30 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-100423-78eecb9f |
| sess_SDA-2026-04-11- | While the debate proposes ADCY8-cAMP-PKA-CREB pathways, the exact molecular step | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-105819-f7d141d0 |
| sess_SDA-2026-04-11- | The debate identified glycolytic shifts and mTOR disruption but couldn't disting | 0.48 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-105826-6e561b44 |
| sess_SDA-2026-04-11- | The debate highlighted receptor desensitization as a critical concern for SPM re | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-110721-4df69d8e |
| sess_SDA-2026-04-04- | How do metabolomic alterations in glucose metabolism, mitochondrial function, an | 0.30 | 7 | 4 | completed | 2026-04-21 | SDA-2026-04-04-frontier-metabolomics-f03b09d9 |
| sess_SDA-2026-04-11- | The debate revealed fundamental uncertainty about whether enhancing TYROBP-SYK s | 0.30 | 0 | 4 | completed | 2026-04-21 | SDA-2026-04-11-gap-debate-20260410-111113-052488a8 |
| sess_SDA-BIOMNI-SPAT | How does spatial gene expression in the hippocampus and entorhinal cortex distin | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-SPATIAL_-c2b61633 |
| sess_SDA-BIOMNI-GENE | What co-expression modules are shared and unique across brain regions in AD, and | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-GENE_COE-55fc5237 |
| sess_SDA-BIOMNI-CELL | Which ligand-receptor interactions between glial and neuronal populations are di | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-CELL_CEL-a7eed9c5 |
| sess_SDA-BIOMNI-CAS1 | Can optimized Cas13 guide RNAs selectively silence pathogenic MAPT splice varian | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-CAS13_PR-d6f415f0 |
| sess_SDA-BIOMNI-PROT | Which proteins are differentially expressed in AD CSF and brain tissue, and do t | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-PROTEOMI-c4a33049 |
| sess_SDA-BIOMNI-BIOM | Can a multi-modal biomarker panel combining plasma proteins, neuroimaging featur | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-BIOMARKE-34ec007c |
| sess_SDA-BIOMNI-CLIN | What is the current clinical trial landscape for AD therapeutics, and which mech | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-CLINICAL-b7a71edd |
| sess_SDA-BIOMNI-BIND | Can computational de novo protein binder design produce stable binders that bloc | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-BINDER_D-0657a9ed |
| sess_SDA-BIOMNI-SURV | Which clinical, genetic, and biomarker features are independent prognostic marke | 0.70 | 0 | 4 | completed | 2026-04-21 | SDA-BIOMNI-SURVIVAL-3e217f4d |
| sess_SDA-BIOMNI-POLY | How well do current AD polygenic risk scores predict disease onset in independen | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-POLYGENI-b3028c7a |
| sess_SDA-BIOMNI-VARI | Which non-coding variants at AD GWAS loci have functional evidence for gene regu | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-VARIANT_-b5b8e32f |
| sess_SDA-BIOMNI-FINE | Can Bayesian fine-mapping of the top 25 AD GWAS loci identify credible sets of c | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-FINE_MAP-215bc2c6 |
| sess_SDA-BIOMNI-GENE | Which transcription factors drive the gene regulatory networks that distinguish | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-GENE_REG-785b71fe |
| sess_SDA-BIOMNI-SCRN | Can standardized scRNA-seq processing and automated annotation identify novel ce | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-SCRNA_AN-248caecc |
| sess_SDA-BIOMNI-MICR | How does the gut microbiome composition differ between PD patients and healthy c | 0.70 | 7 | 4 | completed | 2026-04-21 | SDA-BIOMNI-MICROBIO-337ee37a |
| sess_SDA-2026-04-21- | The fundamental premise remains unvalidated despite extensive mechanistic specul | 0.50 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-21-gap-debate-20260417-033037-c43d12c2 |
| sess_SDA-2026-04-16- | The debate revealed conflicting evidence about whether TRPML1 activation rescues | 0.72 | 3 | 4 | completed | 2026-04-21 | SDA-2026-04-16-gap-debate-20260410-113045-27c7b314 |
| sess_SDA-2026-04-10- | The abstract claims Cdk5 activation is the primary cause of AD, contradicting th | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-10-gap-pubmed-20260410-185251-10f6a211 |
| sess_SDA-2026-04-11- | The debate highlighted a fundamental uncertainty about whether transgenerational | 0.70 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-105844-45a775a2 |
| sess_SDA-2026-04-11- | The debate highlighted focused ultrasound as most feasible but didn't resolve cr | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-110223-e27ddf73 |
| sess_SDA-2026-04-11- | The debate assumed that correcting APOE4's aberrant domain interactions would re | 0.43 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-110241-04eef441 |
| sess_SDA-2026-04-11- | The debate highlighted that speech timing and sleep changes could reflect circad | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-110253-5fa88b6d |
| sess_SDA-2026-04-11- | Multiple participants noted the conflation of cellular dysfunction with senescen | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-110715-ae1eeb19 |
| sess_SDA-2026-04-11- | The debate highlighted that while SCFAs can cross the blood-brain barrier, the a | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-110745-72201cc8 |
| sess_SDA-2026-04-11- | The debate identified systemic toxicity as a major concern for glucosylceramide | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-111106-df334a52 |
| sess_SDA-2026-04-11- | The debate highlighted that RNA granules serve essential physiological functions | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-111130-9967ed0e |
| sess_SDA-2026-04-11- | The debate revealed a fundamental gap: whether disease-specific C1q conformation | 0.51 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-111529-85a3197f |
| sess_SDA-2026-04-11- | The debate highlighted that mitochondrial transfer could be therapeutic, but rai | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-111536-ebde9783 |
| sess_SDA-2026-04-11- | The stage-dependent strategy assumes sequential drug switching is feasible, but | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-111928-22fc607c |
| sess_SDA-2026-04-11- | The debate revealed a critical gap: while PINK1/PARKIN deficiency correlates wit | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-111936-47b73d88 |
| sess_SDA-2026-04-11- | All participants agreed that transcriptomic vulnerability signatures don't estab | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-111936-9a9b8c46 |
| sess_SDA-2026-04-11- | The debate revealed a critical gap: while excitatory neurons show mitochondrial | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-11-gap-debate-20260410-111943-688d4ed6 |
| sess_SDA-2026-04-10- | While genetic evidence links autophagy dysfunction to neurodegeneration, the deb | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-10-gap-debate-20260410-113045-6fcb3f6c |
| sess_SDA-2026-04-10- | The core causation versus correlation debate remains unresolved despite being ce | 0.50 | 0 | 4 | completed | 2026-04-20 | SDA-2026-04-10-gap-debate-20260410-112348-a10cb6b4 |