| h-0ba94d1485 | Small-Molecule FUS Nuclear Import Correctors Rescue Motor Neuron Toxicity | 0.55 | 0.70 | FUS | proposed | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-434c5d45f5 | Dual-Mechanism Model: G2019S Increases Both Baseline AND Signal-Dependent Phosph | 0.55 | 0.55 | LRRK2 | proposed | 2026-04-26 | SDA-2026-04-23-gap-debate-20260417-033119-54941818 |
| h-f5e072feff | TLR2 Recognition of Gut-Derived Fungal and Bacterial D-Alanylated Lipoteichoic A | 0.55 | 0.62 | TLR2, MyD88, NFATC1, PTGS2 (COX-2), PTGER2 (EP2), C3 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425-225305 |
| h-86101c8cd6ec | Developmental stage-specific dominance of tau vs MAP6 function | 0.55 | 0.55 | MAPT | proposed | 2026-04-25 | |
| h-b8724fde927e | Neuronal-specific domain stabilization | 0.55 | 0.55 | ANK2 | proposed | 2026-04-25 | |
| h-a40b5598 | BET Bromodomain Inhibition for Neuroinflammation Suppression | 0.55 | 0.65 | BRD4 | proposed | 2026-04-25 | SDA-2026-04-16-gap-epigenetic-adpdals |
| h-80ac3d8b6e | Metabolic Rescue PDH Activation (H5): Indirect Lipogenesis Suppression | 0.55 | 0.55 | PDHA1 (Pyruvate dehydrogenase α1) | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-180918-962b1ada-debate |
| h-b53b88f02f | GPX4 Activation as Neuroprotective Strategy | 0.55 | 0.70 | GPX4 (glutathione peroxidase 4) | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate |
| h-94d6ba316c | EP4 Receptor Agonism for SLC7A11 Upregulation | 0.55 | 0.58 | PTGER4 (EP4 receptor) → SLC7A11 transcription | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate |
| h-9e877c49ba | Physiological SCFAs may worsen alpha-synuclein pathology through FFAR2/GPR43-NLR | 0.55 | 0.67 | FFAR2/NLRP3/IL1B | proposed | 2026-04-24 | SDA-2026-04-25-gapdebate-18cce7b525 |
| h-d12d82fb56 | GPP Repeat Peptide-Fc Fusion for Enhanced Brain Penetration | 0.55 | 0.52 | SLC15A2 (PepT2); FCGRT (FcRn) | proposed | 2026-04-22 | SDA-2026-04-02-gap-bbb-antibody-transport |
| h-80d39d9095 | Disrupting Muscarinic M1/M3 Receptor-Mediated Tau Internalization and Synaptic T | 0.55 | 0.58 | CHRM1 (M1R) | proposed | 2026-04-22 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-ad2607a5c9 | H7: NEAT1 Epigenetic Rewiring Under Proteotoxic Stress | 0.55 | 0.58 | NEAT1, METTL14, YTHDC1 (m6A reader) | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-120802 |
| h-a3998f0e46 | Surface Exposure of SENP1-β1 Integrin Complex Enables Targeted Senolytic Elimina | 0.55 | 0.52 | SENP1, ITGB1 (β1 integrin), ITGAM (CD11b) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-6af4ba5f |
| h-5b6ec35742 | H2: SASP Neutralization via JAK/STAT Inhibition Preserves Astrocyte Function | 0.55 | 0.52 | IL6R; JAK1; STAT3 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-5d7b9dc0 |
| h-811f3e6d09 | RNA Sequence Elements as Primary Specificity Determinants | 0.55 | 0.58 | TIA1, HuR, FMRP, G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041428-53b81741 |
| h-65d6aa9d6c | oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation | 0.55 | 0.55 | OLR1 (LOX-1), NFE2L2 (Nrf2) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041434-a4d6154a |
| h-25be864e | H63D HFE Genotype-Guided Iron Chelation Therapy for Subset-Selected ALS Patients | 0.55 | 0.55 | HFE (H63D variant) | proposed | 2026-04-16 | SDA-2026-04-16-gap-ferroptosis-als-d2fb6bf796ed |
| h-43ec636e | Oligodendrocyte DNA Repair Enhancement | 0.55 | 0.30 | PARP1 | proposed | 2026-04-13 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-b0cda336 | Digital Twin-Guided Metabolic Reprogramming | 0.55 | 0.50 | PPARGC1A/PRKAA1 | promoted | 2026-04-02 | sda-2026-04-01-gap-012 |
| h-9cd3aac2 | CYP46A1 Activation as a Therapeutic Strategy to Restore Neuronal Cholesterol Eff | 0.55 | 0.60 | CYP46A1 | proposed | 2026-04-25 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-49112ee4c0 | A pre-organized hairpin or loop in lncRNA-0021 creates a high-affinity docking s | 0.55 | 0.46 | lncRNA-0021 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-292a1ec3 | Combined NAMPT-Alectinib Targeting of SASP-Complement Cascade | 0.55 | 0.50 | NAMPT, SIRT1, C1QA/C1QB/C1QC, IL1B | proposed | 2026-04-16 | SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e |
| h-91bdb9ad | Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy | 0.55 | 0.50 | RHOT1 | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401231108 |
| h-a968e9c3b5 | Multi-Chaperone System Co-Activation Prevents Saturation Through Complementary S | 0.55 | 0.72 | DNAJB1, HSP90AA1/HSP90AB1, STIP1 (HOP) | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-3d2aa5a6 | YWHAG-Mediated TFEB Subcellular Targeting | 0.55 | 0.30 | YWHAG | proposed | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222617-8eb5bdbc |
| h-6636218992 | TRIM21-Mediated Ubiquitination Creates Peripheral Epitope Gradient via K63-Linke | 0.55 | 0.58 | TRIM21 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-041423-9c2c2ee3 |
| h-646ae8f1 | Perinatal Hypoxia-Primed Microglia Targeting | 0.55 | 0.30 | HIF1A, NFKB1 | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-69ce9196 | SYK-Independent TREM2 Pathways Remain Functional in TYROBP Deficiency | 0.55 | 0.50 | SYK, TREM2 | promoted | 2026-04-15 | SDA-2026-04-14-gap-pubmed-20260411-072446-a32fa49c |
| h-d2937ed0 | Microglial TREM2-Independent Pathway Activation | 0.55 | 0.60 | DAP12, SYK, PLCG2 | proposed | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222543-20260402 |
| h-d69f2fdd | CNTF-JAK/STAT3 Reprogramming of Trained Microglia to Neuroprotective State | 0.55 | 0.52 | CNTFRα/GP130 → JAK1/JAK2 → p-STAT3(Y705) | proposed | 2026-04-26 | SDA-2026-04-08-gap-debate-20260406-062033-ad87c3fb |
| SDA-2026-04-02-gap-t | Synaptic Vesicle Tau Capture Inhibition | 0.55 | 0.38 | SNAP25 | proposed | 2026-04-16 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-var-297004b1d7 | Gamma-Entrained PV Interneurons Enable p-tau217-Guided Precision Dosing of lncRN | 0.55 | 0.39 | lncRNA-0021, PVALB, CREB1 | promoted | 2026-04-17 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| h-ab3a0af5 | NAD+ Precursor Supplementation to Reverse Poly(ADP-ribose) Polymerase-Driven Met | 0.55 | 0.55 | PARP1, SIRT1/3, NAD+ | proposed | 2026-04-25 | SDA-2026-04-16-frontier-metabolomics-f03b09d9 |
| h-7110565d | Sensory-Motor Circuit Cross-Modal Compensation | 0.55 | 0.20 | CHAT | proposed | 2026-04-04 | SDA-2026-04-03-26abc5e5f9f2 |
| h-9d2bca0f28 | Combined p-tau217 + p-tau231 Panel Increases Specificity for Treatment Cessation | 0.55 | 0.48 | NA - Multi-biomarker diagnostic | proposed | 2026-04-25 | |
| h-var-521f97f447 | Closed-loop transcranial focused ultrasound with real-time gamma feedback to res | 0.55 | 0.82 | PVALB | promoted | 2026-04-17 | SDA-2026-04-03-26abc5e5f9f2 |
| h-528099e954 | Computational Model-Optimized TFUS Parameters for Interneuron Targeting | 0.55 | 0.48 | Hodgkin-Huxley formalism with mechanoelectrical transduction | proposed | 2026-04-28 | SRB-2026-04-28-h-var-a4975bdd96 |
| h-SDA-2026-04-26-gap | Restorative Sleep Induction as the Threshold Mechanism: Dose-Dependent REM Enhan | 0.55 | 0.47 | AQP4 water channels (perivascular astrocyte end-feet), lymph | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-081101-dfe3eacb |
| h-SDA-2026-04-26-gap | 5-HT2A/C Silencing Enables Sustained BDNF-TrkB Signaling for Spine Maintenance | 0.55 | 0.47 | 5-HT2A receptor (HTR2A), BDNF, TrkB (NTRK2), CREB | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260411-081101-dfe3eacb |
| h-SDA-2026-04-26-gap | Co-translational ER Targeting Defect and Lysosomal Delivery Failure | 0.55 | 0.47 | SRP54, SRP68, SRP72 (SRP components); SCARB2 (LIMP-2) | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b |
| h-SDA-2026-04-26-gap | ER-Associated Degradation (ERAD) Cross-Activation | 0.55 | 0.47 | EIF2AK3 (PERK), EIF2S1 (eIF2α); HSPA5 (BiP), XBP1 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260412-094853-199f4f1b |
| h-0c189719 | Co-translational mRNA localization as a sensor for RNA granule trafficking defec | 0.55 | 0.50 | IGF2BP1 (ZBP1), TARDBP (TDP-43 in RNA granules); β-actin ACT | proposed | 2026-04-26 | SDA-2026-04-10-gap-debate-20260410-075000-7396040a |
| h-7857b01b | CD300f Immune Checkpoint Activation | 0.54 | 0.30 | CD300F | proposed | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-7c3c0f40 | Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromatin Remodeling | 0.54 | 0.50 | SIRT1, FOXO3, NRF2, TFAM | proposed | 2026-04-04 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-fdaae8d9 | Trans-Synaptic Adhesion Molecule Modulation | 0.54 | 0.34 | NLGN1 | proposed | 2026-04-02 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-c9486869 | HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor | 0.54 | 0.45 | DNAJB6 | proposed | 2026-04-02 | SDA-2026-04-01-gap-9137255b |
| h-019ad538 | Temporal Decoupling via Circadian Clock Reset | 0.54 | 0.70 | CLOCK | debated | 2026-04-02 | sda-2026-04-01-gap-009 |
| h-b3f9d8eb | HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting in P/Q Channel Defi | 0.54 | 0.71 | HCN1 | proposed | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-181156-feec7bd3 |
| h-var-e399c10fff | TREM2-GluN2B Circuit: Microglial Control of Thalamocortical Oscillations and Gly | 0.54 | 0.67 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-03-26abc5e5f9f2 |