| hyp_test_490ced0b | Test: TREM2 enhances amyloid clearance | 0.54 | 0.28 | TREM2 | proposed | 2026-04-17 | test-hypothesis-fixtures-v1 |
| h-e064f134 | BMP4 Pathway Inhibition for Oligodendrocyte Myelination Support | 0.54 | 0.50 | BMP4 and BMPR1A | proposed | 2026-04-04 | SDA-2026-04-03-gap-seaad-v2-20260402032945 |
| h-758b4994eb | Synaptic Vulnerability Window Temporal Targeting: Transient SPP1 Blockade | 0.54 | 0.52 | SPP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd |
| h-01b8a985c4 | CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering | 0.54 | 0.55 | SPP1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-062118-5e49e14f |
| h-8ebce483d2 | Transient Chaperone Priming Prior to Seed Inoculation Prevents Propagation by Re | 0.54 | 0.62 | HSF1, NFE2L2 (NRF2), HSPA1A, DNAJB1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062052-28cbc764 |
| h-b36986e26d | Entorhinal Cortex (EC)-Hippocampus Closed-Loop Interface Restores Layer-Specific | 0.54 | 0.52 | RELN/GRIA1 | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e95d2d1d86 |
| h-c1aec6a4 | Neuron-Specific Expression of Autophagy Inhibitory Phosphatases (PP2A/Bβ1) | 0.54 | 0.55 | PPP2R2B, ULK1 complex | proposed | 2026-04-26 | SDA-2026-04-07-gap-pubmed-20260406-062212-ca78691c |
| h-94e73015 | CSF1R Partial Agonism Combined with TREM2 Activation for ALS Neuroprotection | 0.54 | 0.58 | CSF1R Partial | proposed | 2026-04-26 | SDA-2026-04-17-gap-microglial-subtypes-pharmaco-202604170000 |
| h-5d68a7d2 | Microglial TREM2 Activation to Enhance Synaptic Pruning Regulation | 0.53 | 0.65 | Microglial TREM2 | proposed | 2026-04-26 | SDA-2026-04-16-frontier-connectomics-84acb35a |
| h-0a1650e6 | NFκB/C1Q SASP Modulation for Synaptic Protection | 0.53 | 0.58 | C1Q | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-181340-8acb24dc |
| h-analogy-bb6d7fb1 | Closed-loop orexin receptor modulation to entrain circadian glymphatic clearance | 0.53 | 0.40 | HCRTR1/HCRTR2 (orexin receptor genes) | active | 2026-04-28 | |
| h-959a4677 | Blood-Brain Barrier SPM Shuttle System | 0.53 | 0.70 | TFRC | debated | 2026-04-02 | sda-2026-04-01-gap-014 |
| h-ae4a2281 | PLIN2 (Perilipin-2) Degradation via Autophagy Activation to Clear Disease-Associ | 0.53 | 0.55 | PLIN2/NEDD4L (Lipophagy) | proposed | 2026-04-26 | SDA-2026-04-16-frontier-lipidomics-dcdbc360 |
| h-6c83282d | Gut Barrier Permeability-α-Synuclein Axis Modulation | 0.53 | 0.60 | CLDN1, OCLN, ZO1, MLCK | proposed | 2026-04-02 | SDA-2026-04-01-gap-20260401-225155 |
| h-5afacdfe | Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interfa | 0.53 | 0.60 | LDHA, TREM2 | proposed | 2026-04-12 | SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222618-c69 |
| h-0f025d94 | PLCG2 Allosteric Modulation as a Precision Therapeutic for TREM2-Dependent Micro | 0.53 | 0.50 | PLCG2 | proposed | 2026-04-17 | SDA-2026-04-01-gap-001 |
| h-test-full-8d254307 | EV-Mediated Epigenetic Reprogramming | 0.53 | 0.60 | EVs/miRNAs | proposed | 2026-04-11 | sda-2026-04-12-ev-ad-biomarkers |
| h-7dfdc5d7 | Mitochondrial-Cytokine Axis Modulation | 0.53 | 0.70 | Mitochondrial respiratory complexes and inflammatory cytokin | promoted | 2026-04-04 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-var-b7e8e12838 | TBK1 Loss Drives Motor Neuron Death Through Impaired Mitophagy and Metabolic Col | 0.53 | 0.34 | TBK1 → OPTN / p62 / FIP200 / mitophagy machinery | proposed | 2026-04-27 | SDA-2026-04-26-gap-20260425215446 |
| h-a947032c | Glucose-Ketone Metabolic Switch Timing | 0.53 | 0.30 | GLUT1/GLUT3/MCT1/MCT2 | proposed | 2026-04-17 | SDA-2026-04-03-gap-debate-20260403-222618-2709aad9 |
| h-4fabd9ce | Cryptic Exon Silencing Restoration | 0.53 | 0.70 | TARDBP | debated | 2026-04-02 | sda-2026-04-01-gap-v2-68d9c9c1 |
| h-metrep-623b0389f6c | CyclinD1-Tagged Partial Cellular Reprogramming via Modified Yamanaka Cocktail Re | 0.53 | 0.75 | OCT4,POU5F1,SOX2,KLF4,MYC,CCND1,CDKN2A,CDKN1A,MAP2,NEUN,SYN1 | proposed | 2026-04-28 | |
| h-analogy-2be480e6 | Closed-loop neuromodulation-inspired cytokine axis suppression to restore Cx43 h | 0.53 | 0.35 | GJA1 (Cx43) | active | 2026-04-28 | |
| h-5c9b3fe9 | Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes | 0.53 | 0.55 | Polycomb-to-Trithorax Switch at | proposed | 2026-04-26 | SDA-2026-04-19-gap-epigenetic-comparative-ad-pd-als |
| h-56a149a41c | NAC + Ferrostatin-1 Combination for Peroxynitrite-Ferroptosis Crosstalk | 0.53 | 0.62 | Convergent: GSH depletion + peroxynitrite + lipid radical ac | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate |
| h-658167b004 | GDNF-RET Trophic Signaling Deficit | 0.53 | 0.50 | GDNF; RET; VCP | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-170057-a2f72fd8-debate |
| h-d083850487 | TREM2-dependent microglial phagocytosis of tau seeds | 0.53 | 0.50 | TREM2/Syk/PLCγ2 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |
| h-c98d1cb4e7 | AAV-mediated RGS6 re-expression in SNpc after pathology onset | 0.53 | 0.42 | RGS6 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-145520-5692b02e-debate |
| h-851ef04ad8 | Dendritic tau missorting persists through local proteostatic failure in endolyso | 0.53 | 0.56 | MAPT,RAB5,RAB7,LAMP1,TFEB | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-98a600b3ed |
| h-2842eb0a8b | C1q shows synapse-class-specific roles, with inhibitory versus excitatory synaps | 0.53 | 0.52 | C1QA,C1QB,C1QC,GAD1,GAD2,SLC6A1,SLC17A7,ITGAM,ITGB2 | proposed | 2026-04-25 | SDA-2026-04-25-gapdebate-afba1a80bd |
| h-0ba5108157 | Oligodendrocyte Lineage Vulnerability: Early Myelination Disruption with Blocked | 0.53 | 0.55 | PDGFRα | proposed | 2026-04-22 | SDA-2026-04-02-gap-seaad-debate-v4 |
| h-428057939b | Modulating Tunneling Nanotube (TNT) Formation via M-Sec/Noradrenaline Signaling | 0.53 | 0.48 | TNFRSF12A (M-Sec) | proposed | 2026-04-22 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-e9c2d00456 | H4: Polycomb Repression Relaxes at Neurodevelopment Genes | 0.53 | 0.61 | EZH2, H3K27me3, CBX proteins | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-120802 |
| h-ebf902e71c | PI3P Generation at Damaged Lysosomes Promotes Membrane Repair | 0.53 | 0.48 | PIK3C3/VPS34, CHMP2A | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-a6cc7467 |
| h-26d64f6a47 | Therapeutic Repurposing: C1-INH as Plaque-Stabilizing Agent | 0.53 | 0.52 | C1R/C1S | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-fcd35131cf | C1Q-Angiogenic Axis Promoting Plaque Neovascularization | 0.53 | 0.55 | C1QA/C1QC | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-c381434159 | CX3CR1-Targeted AntimiR-155 Oligonucleotides for Microglial Priming Reversal | 0.53 | 0.58 | MIR155 (microRNA-155) | proposed | 2026-04-21 | SDA-2026-04-08-gap-debate-20260406-062039-47e9c8cf |
| h-5ff6c5ca | Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioenergetics | 0.53 | 0.30 | SLC16A2 | debated | 2026-04-02 | sda-2026-04-01-gap-004 |
| h-2a4e4ad2 | PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor Mitochondria | 0.53 | 0.50 | BNIP3/BNIP3L | proposed | 2026-04-03 | SDA-2026-04-01-gap-20260401231108 |
| h-115a27fb8c | DNMT1 Compensation Window During Synaptic Resilience Phase | 0.53 | 0.60 | DNMT1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b |
| h-37fc3b23a5 | Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA | 0.53 | 0.50 | IGFBPL1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf |
| h-8520098f4d | Neurodevelopmental Sex Differences in Thalamocortical GluN2B-Glymphatic Coupling | 0.53 | 0.48 | Developmental GRIN2B expression timing; AQP4 astrocyte matur | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e2b5a7e7db |
| h-5137be61 | Neuronal Integrated Stress Response Modulation | 0.53 | 0.60 | EIF2AK3 (PERK) and EIF2B complex | proposed | 2026-04-04 | SDA-2026-04-03-gap-seaad-v2-20260402032945 |
| h-5626c1f2 | Temporal Metabolic Window Therapy | 0.53 | 0.70 | HMGCS2 | promoted | 2026-04-12 | SDA-2026-04-04-gap-debate-20260403-222618-e6a431dd |
| h-910e7283b7 | Epigenetic CRISPR/dCas9 Activation of PV Gene Program Prevents Aβ-Induced Transc | 0.53 | 0.50 | DNMT3A/PVALB promoter | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e95d2d1d86 |
| h-332083afc1 | Sleep-Stage TFUS to Restore SWR-Gamma Coupling and Memory Consolidation | 0.53 | 0.40 | CB1 (CNR1), HCN1, Kv3.1 (KCNC1) | proposed | 2026-04-28 | SRB-2026-04-28-h-var-a4975bdd96 |
| h-2b545285ee | Glucosylceramide accumulation nucleates alpha-synuclein aggregation via lipid ra | 0.53 | 0.72 | GBA | proposed | 2026-04-27 | sda-2026-04-01-002 |
| h-c7350d53bb | Gut-derived butyrate reprograms microglia for amyloid clearance via HDAC2 inhibi | 0.53 | 0.72 | HDAC2 | proposed | 2026-04-27 | sda-2026-04-01-003 |
| h-64e3588957 | TREM2 Epigenetic Window for Microglial Lipid Metabolism | 0.53 | 0.55 | TREM2/HDAC1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062039-7ef9980b |
| h-1e2b7f1c | VPS35 Retromer Restoration to Rescue Endosomal Protein Trafficking | 0.52 | 0.53 | VPS35 (VPS26/VPS29/VPS35 complex) | proposed | 2026-04-26 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |