C4B

C4B Protein

Score: 0.337 Price: $0.34 Undruggable Druggability Status: active Wiki: C4B Gene

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 C4B — PDB 4FXK Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.23

Clinical Stage

Preclinical

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippocampal CA1 Neurons

Known Drugs:

No known drugs targeting this protein

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: P0C0L5

🧬 3D Protein Structure

🧬 C4B — PDB 4FXK Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for P0C0L5

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Linked Hypotheses (0)

No linked hypotheses

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

Debate History (1)

Should C4B (C4B Protein) be prioritized as a therapeutic target for neurodegener2026-04-26

C4B

3D Protein Structure

Druggability & Clinical Context

🧬 3D Protein Structure

3D Protein Structure (AlphaFold)

Linked Hypotheses (0)

Linked Experiments (0)

Scoring Dimensions

Knowledge Graph (20)

activates (2)

associated with (4)

component of (1)

expressed in (3)

interacts with (2)

mediates (1)

pathology linked to (1)

pathway partner (1)

regulated by (2)

regulates (1)

repressed by (1)

therapeutic target of (1)

Debate History (1)