gene 689 words KG: JUN 2026-03-24
kind:genesection:genesstate:published
Contents

JUN Gene

🧬 Gene Info
Gene SymbolJUN
Full NameJun Proto-Oncogene, AP-1 Transcription Factor Subunit
Chromosome1p32.1
Protein TypeTranscription Factor
Functionc-Jun/AP-1 is a key transcription factor
Primary Expressionproliferating neural progenitors and migrating neurons, declining to lower basal levels in the adult brain
PathwaysAkt, Amyloid, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt IDP45985
NCBI Gene ID3715
Ensembl IDENSG00000100994
OMIM165160
GeneCardsJUN
Human Protein AtlasJUN
StrategyCompound/Mechanism
JNK inhibitorsSP600125, D-JNKI1
Associated DiseasesALS, ALZHEIMER'S DISEASE, Addiction, Aging, Alzheimer
Known Drugs/Compoundspokeweed mitogen, anti-CD3, quercetin, burn serum
InteractionsHCN1, HCN4, HCN2, NTN1, MIRO1, MAPT
KG Connections2523 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Piezoelectric Nanochannel BBB Disruption
Score: 0.41
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
AKT1 Gene
gene · KG edge: activates
ADRA1D Gene
gene · KG edge: regulates
ADCY9 Gene
gene · KG edge: regulates
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

JUN associated_with BCL2
JUN associated_with MAP1LC3B
JUN associated_with TFEB
JUN associated_with BDNF
JUN associated_with Alzheimer's disease
JUN associated_with Amyotrophic Lateral Sclerosis
JUN associated_with Cardiovascular
JUN associated_with ATG
JUN associated_with Fibrosis
JUN associated_with Neuroinflammation