Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COMPLEMENT_CASCADE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| C4B | component_of | gene | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SASP-Mediated Complement Cascade Amplification | 0.703 | neurodegeneration | Senolytic therapy for age-related neurod |
| Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc | 0.587 | neuroinflammation | What molecular mechanisms drive the tran |
| Senescent Cell ASM-Complement Cascade Intervention | 0.552 | neurodegeneration | Lipid raft composition changes in synapt |
| Complement Cascade Activation Bridges Microglial OxPC Sensin | 0.452 | neuroinflammation | What molecular mechanisms enable microgl |
Scientific analyses that reference this entity
Neuroinflammation | 2026-04-03 | 1 hypotheses Top: 0.522
Neuroinflammation | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887] | Chen TY, Wu N, Sun X | Life (Basel) | 2026 | 1 |
| Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276] | Voicu V, Toader C, Șerban M, Covache-Bus | Biomedicines | 2025 | 1 |
| Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614] | Han QQ, Shen SY, Liang LF, Chen XR, Yu J | Brain Behav Immun | 2024 | 1 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455] | Cornell J, Salinas S, Huang HY, Zhou M | Neural Regen Res | 2022 | 1 |
| Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548] | Hong S, Beja-Glasser VF, Nfonoyim BM, Fr | Science | 2016 | 1 |
| Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors i [PMID:41914021] | Xie M, Feng L, Li R, Li M, Shen L, Zhang | CNS neuroscience & therapeutic | 2026 | 0 |
| Vaccine-induced antibodies can limit Salmonella infection in the absence of comp [PMID:41738756] | Perez-Toledo M, Aksu-Istil K, Marcial-Ju | mBio | 2026 | 0 |
| The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436] | Gopalakrishna PK, Che Mohd Nassir CMN, A | Cellular and molecular neurobi | 2026 | 0 |
| Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-C [PMID:41766448] | Taxiarchis A, Pruner I | Current opinion in hematology | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974] | Dai L, Wang J, Meng L, Zhang X, Xiao T, | PLoS biology | 2025 | 0 |
| PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of [PMID:39947489] | Zhao Q, Zeng C, Luo F, Xian Z, Wen H, Tu | Brain, behavior, and immunity | 2025 | 0 |
| Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment s [PMID:39825014] | Chestnykh D, Mühle C, Schumacher F, Kali | Mol Psychiatry | 2025 | 0 |
| Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and P [PMID:40166037] | Cruchaga C, Heo G, Thomas A, Wang E, Oh | Res Sq | 2025 | 0 |
| Reduction of sphingomyelinase activity associated with progranulin deficiency an [PMID:40633679] | Boyle NR, Fox SN, Tadepalli AS, Seyfried | Neurobiol Dis | 2025 | 0 |
| Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflamma [PMID:38342616] | Ambrin G, Kang YJ, Van Do K, Lee C, Sing | Advanced science (Weinheim, Ba | 2024 | 0 |
| Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric [PMID:38456789] | ["Zhu J", "Wei R", "Hu G", "Wang H", "Wa | Small (Weinheim an der Bergstr | 2024 | 0 |
| The Role of Complement Dysregulation in Glaucoma. [PMID:38396986] | ["Hoppe C", "Gregory-Ksander M"] | International journal of molec | 2024 | 0 |
| Retracted: Ginsenoside Rg1 Ameliorates Acute Renal Ischemia/Reperfusion Injury v [PMID:38234567] | ["Longevity O"] | Oxidative medicine and cellula | 2024 | 0 |