SPTLC1

SPTLC1 Protein

Score: 0.489 Price: $0.43 Medium Druggability Status: active

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 SPTLC1 — PDB 4HWL Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Medium

Score: 0.50

Clinical Stage

Phase I

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Therapeutic Areas:

neurodegeneration

Mechanism: Prioritized from 1 SciDEX hypotheses, including: APOE-Mediated Synaptic Lipid Raft Stabilization

Known Drugs:

No known drugs targeting this protein

Structural Data:

🧬 3D Protein Structure

🧬 SPTLC1 — PDB 4HWL Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Linked Hypotheses (1)

APOE-Mediated Synaptic Lipid Raft Stabilization0.426

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

...and 1 more

expressed in (2)

SPTLC1 → KCNJ6

SPTLC1 → STRAP

inhibits (1)

SPTLC1 → ABCA1

interacts with (1)

SPTLC1 → ORMDL proteins

involved in (2)

SPTLC1 → Sphingolipid biosynthesis

SPTLC1 → 1-Deoxysphingolipids

regulates (1)

SPTLC1 → Sphingolipid metabolism

Debate History (0)

No debates yet