protein 2,786 words KG: CLUSTERINPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:publishedevidence:strong
Contents

Clusterin Protein

🔬 Protein Info
Gene SymbolCLU
Full NameClusterin
AliasesPage for CLU Gene
Chromosome8p21.1.
Protein FamilyApolipoprotein / extracellular chaperone
FunctionIt binds to non-native, misfolded, or aggregation-prone proteins and maintains them in a soluble state suitable for subsequent processing (Wyatt et al., 2009)
Primary ExpressionSecreted (sCLU), cytoplasmic/nuclear (nCLU/iCLU)
Subcellular Localization[@poon2000]
Molecular Weight80 kDa
Amino Acids522 aa
Exons9
PathwaysApoptosis, Complement, Immune Response, Mitophagy
UniProt IDP10909
NCBI Gene ID1115
Ensembl IDENSG00000120885
OMIM185551
GeneCardsCLU
Human Protein AtlasCLU
Associated DiseasesALS, Aging, Alzheimer, Alzheimer Disease, Alzheimer'S Disease
InteractionsLC3, C1Q, BACE1, PI3K, AKT, BAX
KG Connections292 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (27)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
CYP46A1 Overexpression Gene Therapy
Score: 0.63
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (17)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (5)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40
Biomechanical Impact Profiles and Chronic Traumatic Encephal
clinical · proposed · Score: 0.40
Parkinson's Disease Subtype Classification — Precision Medic
clinical · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 16 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 16 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 16 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 16 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 16 hypotheses