gene 1,612 words KG: SPTLC2 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

SPTLC2 Gene

🧬 Gene Info
Gene SymbolSPTLC2
Full NameSerine Palmitoyltransferase Long Chain Base Subunit 2
Chromosome14q31.3
Function### Serine Palmitoyltransferase Activity
Primary Expressionvarious brain regions:
Molecular Weight62 kDa
Amino Acids422 aa
Exons12
UniProt IDO15270
NCBI Gene ID9517
Ensembl IDENSG00000166800
OMIM610313
GeneCardsSPTLC2
Human Protein AtlasSPTLC2
Alternative NamesSPT2, SPT small subunit 2, LCB2
Associated DiseasesNeuropathy
InteractionsSPTLC1, SYNE2, Raf, ADRA2A, ALDH1A2, IDH1
KG Connections46 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.43
Noradrenergic-Tau Propagation Blockade
Score: 0.51
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Ganglioside Rebalancing Therapy
Score: 0.50

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Sphingolipid Metabolism in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: expressed_in
SPTLC1 - Serine Palmitoyltransferase
gene · KG edge: expressed_in
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: regulates

Knowledge Graph (12 edges)

SPTLC2 expressed_in SPTLC1
SPTLC2 regulates SPTLC1
SPTLC2 regulates ABCA1
SPTLC2 interacts_with SPTLC1
SPTLC2 expressed_in Rb
SPTLC2 activates SYNE2
SPTLC2 expressed_in Als
SPTLC2 expressed_in Lipid Metabolism
SPTLC2 interacts_with Cholesterol
SPTLC2 interacts_with Macrophage