| Gene Symbol | ADCY5 |
| Full Name | Adenylate cyclase 5 |
| Chromosome | 3q21.1 |
| Function | is a large integral membrane protein (approximately 150 kDa) with a characteristic architecture consisting of |
| Primary Expression | Highest in striatum, nucleus accumbens, cortex |
| Molecular Weight | 150 kDa |
| Amino Acids | 1264 aa |
| Exons | 34 |
| UniProt ID | [O76074](https://www.uniprot.org/uniprot/O76074) |
| Ensembl ID | ENSG00000108055 |
| GeneCards | ADCY5 |
| Human Protein Atlas | ADCY5 |
| G protein regulation | Activated by Gαs/Gαolf subunits; inhibited by Gαi/o subunits |
| Forskolin sensitivity | AC5 is highly responsive to forskolin, a plant diterpene that directly activates adenylate cyclases |
| Calmodulin binding | AC5 is unique among adenylate cyclases in being inhibited by calmodulin in a calcium-dependent manner |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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