gene 547 words KG: MET 2026-03-21
kind:genesection:genesstate:published
Contents

MET - MET Proto-Oncogene, Receptor Tyrosine Kinase

🧬 Gene Info
Gene SymbolMET
Full NameMET Proto-Oncogene, Receptor Tyrosine Kinase
AliasesPage for MET, c-Met
Chromosome7q31.2
Protein TypeReceptor
Functionis a receptor tyrosine kinase (RTK) that plays crucial roles in embryonic development, tissue regeneration, and adult tissue homeostasis.
Molecular Weight~140 kDa (precursor), ~170 kDa (mature)
Amino Acids1390 aa
Exons21
PathwaysKey Effectors
UniProt IDP08581
NCBI Gene ID4233
Ensembl IDENSG00000105976
OMIM164860
GeneCardsMET
Human Protein AtlasMET
Associated DiseasesAD, ALI, AMI, Aging, Als, Alzheimer
Known Drugs/Compoundsresveratrol, metformin, PLB-1001
InteractionsBRAF, EGFR, C1Q, MIRO1, MCL1, VEGFA
KG Connections662 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
APOE Isoform Expression Across Glial Subtypes
Score: 0.48
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.48

Related Analyses (11)

Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (1)

AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 7 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 7 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 7 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 7 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 7 hypotheses

Knowledge Graph (12 edges)

MET therapeutic_target SMARCA4
MET therapeutic_target TERT
MET therapeutic_target JUN
MET therapeutic_target EEF1A1
MET therapeutic_target MCL1
MET therapeutic_target MMP9
MET therapeutic_target VIM
MET therapeutic_target TPM2
MET therapeutic_target NCF1
MET associated_with LDLR