gene 1,313 words KG: CD44 2026-03-22
kind:genesection:genesstate:published
Contents

CD44 - Cell Surface Glycoprotein

🧬 Gene Info
Gene SymbolCD44
Full NameCell Surface Glycoprotein
AliasesPage for CD44
Chromosome11p13
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight95 kDa
Amino Acids341 aa
Exons19
PathwaysNF-κB, TGF-β
NCBI Gene ID2115452
Ensembl IDENSG00000026508
GeneCardsCD44
Human Protein AtlasCD44
Associated DiseasesALS, Aging, Alzheimer, Cardiac, Fibrosis
InteractionsSOX2, EGFR, C1Q, SMAD4, GFAP, HMOX1
KG Connections795 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (23)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Blood-Brain Barrier SPM Shuttle System
Score: 0.55

Related Analyses (7)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (13)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
APC Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CD44 interacts_with STROKE
CD44 therapeutic_target ALDH1A1
CD44 therapeutic_target FGF18
CD44 therapeutic_target ATF3
CD44 therapeutic_target IL10
CD44 therapeutic_target DKK1
CD44 therapeutic_target PPARD
CD44 therapeutic_target CLDN1
CD44 therapeutic_target APC
CD44 therapeutic_target AXIN1