pathway

COMPLEMENT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COMPLEMENT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3428Connections

14Hypotheses

10Analyses

50Outgoing

50Incoming

Summary

COMPLEMENT is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 1045 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	COMPLEMENT
Key Genes/Proteins	ASTROCYTES, C1Q, MICROGLIA, NEUROINFLAMMATION
Related Diseases	Als, Aging, Inflammation, Alzheimer, Neurodegeneration
Related Pathways	Complement
Linked Hypotheses	16 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    COMPLEMENT["COMPLEMENT"] -->|"regulates"| SYNAPSE_ELIMINATION["SYNAPSE_ELIMINATION"]
    COMPLEMENT["COMPLEMENT"] -->|"activates"| Als["Als"]
    COMPLEMENT["COMPLEMENT"] -->|"activates"| Ms["Ms"]
    COMPLEMENT["COMPLEMENT"] -->|"interacts"| Als_1["Als"]
    COMPLEMENT["COMPLEMENT"] -->|"interacts"| Autism["Autism"]
    COMPLEMENT["COMPLEMENT"] -->|"therapeutic target"| Als_2["Als"]
    CEBPB["CEBPB"] -->|"regulates"| COMPLEMENT["COMPLEMENT"]
    NPTX2["NPTX2"] -->|"regulates"| COMPLEMENT["COMPLEMENT"]
    IGF2BP1["IGF2BP1"] -->|"interacts"| COMPLEMENT["COMPLEMENT"]
    ANK2["ANK2"] -->|"interacts"| COMPLEMENT["COMPLEMENT"]
    style COMPLEMENT fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1378)

Target	Relation	Type	Str
ASTROCYTES	activates	gene	1.00
C1Q	activates	gene	1.00
Als	activates	disease	1.00
Complement	activates	pathway	1.00
MICROGLIA	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Complement	therapeutic_target	pathway	1.00
Aging	activates	disease	1.00
NEUROINFLAMMATION	activates	gene	1.00
Inflammation	activates	disease	1.00
Alzheimer	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Complement	associated_with	pathway	1.00
Complement	regulates	pathway	1.00
Complement	inhibits	pathway	1.00
ALZHEIMER	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Phagocytosis	activates	pathway	1.00
MICROGLIA	therapeutic_target	gene	1.00
CYTOKINES	activates	gene	1.00
AMYLOID	activates	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
NEURON	activates	gene	1.00
Cancer	therapeutic_target	disease	0.95
Als	regulates	disease	0.95
Als	associated_with	disease	0.95
NEUROMYELITIS OPTICA SPECTRUM DISORDER	therapeutic_target	entity	0.90
Complement	contributes_to	pathway	0.90
Oxidative Stress	activates	pathway	0.90
MICROGLIA	regulates	gene	0.90
Immune Response	regulates	pathway	0.90
Complement	implicated_in	pathway	0.90
PHAGOCYTOSIS	activates	gene	0.90
Neurodegeneration	therapeutic_target	disease	0.85
Alzheimer	associated_with	disease	0.85
Neurodegeneration	regulates	disease	0.85
Inflammation	regulates	disease	0.85
Alzheimer	inhibits	disease	0.85
Alzheimer	therapeutic_target	disease	0.85
Parkinson	activates	disease	0.85
Infection	activates	disease	0.85
Als	inhibits	disease	0.85
Immune Response	therapeutic_target	pathway	0.80
C1Q	regulates	gene	0.80
NEURODEGENERATIVE DISEASES	activates	gene	0.80
C1Q	inhibits	gene	0.80
GENES	activates	gene	0.80
SYNAPSE	inhibits	gene	0.80

Incoming (2050)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	1.00
TAU	activates	gene	0.90
MICROGLIA	interacts_with	cell_type	0.86
CEBPB	regulates	gene	0.85
NEURODEGENERATION	therapeutic_target	gene	0.80
NEURODEGENERATION	regulates	gene	0.80
TREM2	therapeutic_target	gene	0.80
APOPTOSIS	activates	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
PARKINSON'S DISEASE	activates	gene	0.80
NPTX2	regulates	protein	0.72
ALZHEIMER'S DISEASE	activates	gene	0.70
MICROGLIA	activates	gene	0.70
UBIQUITIN	activates	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
APOE	associated_with	gene	0.70
TNF	regulates	gene	0.70
NEURODEGENERATION	associated_with	gene	0.70
BDNF	associated_with	gene	0.70
AMYLOID	activates	gene	0.70
C1QA	activates	gene	0.70
NEURODEGENERATIVE DISEASES	activates	gene	0.70
GENES	associated_with	gene	0.70
ANXIETY	activates	gene	0.70
GENES	activates	gene	0.70
C1Q	activates	gene	0.70
CR1	associated_with	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
DEMENTIA	inhibits	gene	0.70
AQP4	activates	gene	0.70
CYTOKINES	activates	gene	0.70
SYNAPTIC PRUNING	implicated_in	gene	0.70
IGF2BP1	interacts_with	gene	0.60
ANK2	interacts_with	gene	0.60
AGING	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
CFH	activates	gene	0.60
AKT2	activates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
CD44	regulates	gene	0.60
COP1	activates	gene	0.60
AGING	contributes_to	gene	0.60
MMP9	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
TREM2	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CTSH	interacts_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
C1Q	inhibits	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60

Targeting Hypotheses (14)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Mediated Complement Cascade Amplification	0.703	neurodegeneration	Senolytic therapy for age-related neurod
Targeting SASP-Complement Amplification Through HIF-1α Downs	0.610	neurodegeneration	What molecular mechanism causes VCP muta
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.587	neuroinflammation	What molecular mechanisms drive the tran
Complement C1q Suppression as Mechanism Linking Exercise Pla	0.560	neurodegeneration	What are the specific circulating factor
Senescent Cell ASM-Complement Cascade Intervention	0.552	neurodegeneration	Lipid raft composition changes in synapt

Microglial TREM2-Complement Axis Modulation	0.527	neurodegeneration	Cell type vulnerability in Alzheimer's D
Complement C1q Mimetic Decoy Therapy	0.479	neurodegeneration	Synaptic pruning by microglia in early A
Complement C1QA Inhibition Synergizes with PV Interneuron Mo	0.473	neurodegeneration	What molecular mechanisms underlie the d
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu	0.470	neurodegeneration	Gene expression changes in aging mouse b
Complement Cascade Activation Bridges Microglial OxPC Sensin	0.452	neuroinflammation	What molecular mechanisms enable microgl
Complement C1q Subtype Switching	0.437	neurodegeneration	4R-tau strain-specific spreading pattern
Complement C1QA Spatial Gradient in Cortical Layers	0.428	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen
Complement-Mediated Synaptic Protection	0.410	neurodegeneration	Neuroinflammation and microglial priming
Complement-Mediated Synaptic Pruning Dysregulation	0.398	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (10)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274]	Xu F, Han L, Wang Y, Deng D, Ding Y, Zha	BMC Med	2023	2
Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024]	De Schepper S, Ge JZ, Sierksma A, Crowle	Nat Neurosci	2023	2
An integrative analysis of single-cell and bulk transcriptome and bidirectional [PMID:38179058]	Cui HK, Tang CJ, Gao Y, Li ZA, Zhang J,	Front Immunol	2023	2
Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887]	Chen TY, Wu N, Sun X	Life (Basel)	2026	1
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
Early complement genes are associated with visual system degeneration in multipl [PMID:31289819]	Fitzgerald KC, Kim K, Smith MD, Aston SA	Brain	2019	1
Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548]	Hong S, Beja-Glasser VF, Nfonoyim BM, Fr	Science	2016	1
Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: se [PMID:41853292]	Zhai X, Lin X, Zhang L, Ren Y, Miao H, M	Frontiers in immunology	2026	0
Proteomic Signature in Men with Central Serous Chorioretinopathy. [PMID:41641862]	Chambon C, Picard E, Zola M, Aichedo S,	Journal of proteome research	2026	0
Machine Learning and Blood-Targeted Proteomics Enable Early Prediction and Etiol [PMID:41683823]	Starodubtseva N, Tokareva A, Kononikhin	International journal of molec	2026	0
Club cell RhoA activation amplifies allergic airway inflammation by regulating e [PMID:41633491]	Tu W, Wu M, Wan R, Alphonse M, Gu W, Gho	The Journal of allergy and cli	2026	0
Identifying the hub genes in macrophage infiltration and verifying of the role o [PMID:41730938]	Tang L, Xu Y, Nong Z, Li F, Pan L	Scientific reports	2026	0
Repurposing of doxycycline as a novel therapeutic avenue for management of parki [PMID:41925933]	Ali NH, Al-Kuraishy HM, Hussain NR, Al-G	Inflammopharmacology	2026	0
Histological findings in follow-up liver biopsies up to 15 years after pediatric [PMID:41370831]	Quintero-Bernabeu J, Salcedo-Allende MT,	Liver Transpl	2026	0
Protein Corona Reprograms Hepatic Clearance Pathways of Biomimetic Nanoparticles [PMID:41944292]	He T, Fang X, Zhu L, Fan H, Qiu Y et al.	Small	2026	0
Mid-Term Comparison of N-Butyl Cyanoacrylate, Endovenous Laser Ablation, and Rad [PMID:41964281]	Dilek I, Kocaoglu AS, Büyükceran EU, Nay	Vasc Endovascular Surg	2026	0

COMPLEMENT

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Pathway Diagram

Outgoing (1378)

Incoming (2050)

Targeting Hypotheses (14)

Mentioning Analyses (10)

Can pathological vs physiological C1q tagging be distinguished at the molecular

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

What are the specific molecular mechanisms by which C1Q components drive atheros

Neuroinflammation and microglial priming in early Alzheimer's Disease

Immune atlas neuroinflammation analysis in neurodegeneration

Immune atlas neuroinflammation analysis in neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Related Papers (20)

COMPLEMENT

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Parthanatos in Neurodegeneration

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

nimodipine-als

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

NRF2 Oxidative Stress Pathway

Frontotemporal Dementia (FTD)

Pathway Diagram

Outgoing (1378)

Incoming (2050)

Targeting Hypotheses (14)

Mentioning Analyses (10)

Can pathological vs physiological C1q tagging be distinguished at the molecular

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

What are the specific molecular mechanisms by which C1Q components drive atheros

Neuroinflammation and microglial priming in early Alzheimer's Disease

Immune atlas neuroinflammation analysis in neurodegeneration

Immune atlas neuroinflammation analysis in neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Related Papers (20)