gene 1,570 words KG: WDR41 2026-03-27
kind:genesection:genesstate:published
Contents

WDR41 Gene

🧬 Gene Info
Gene SymbolWDR41
Full NameWD Repeat Domain 41
AliasesWDR41 gene encoding WD repeat domain 41
Chromosome9p21.1
Functionencodes a protein containing WD40 repeat domains that mediate protein-protein interactions.
Primary Expressionmost human tissues: - Brain: High expression in neurons - Liver: Metabolic functions - Kidney: Transport functions - Muscle: High ener
Molecular Weight~42 kDa
Amino Acids376 aa
PathwaysMtor
UniProt IDQ9H0X4
NCBI Gene ID25828
Ensembl IDENSG00000137265
OMIM614739
GeneCardsWDR41
Human Protein AtlasWDR41
Associated DiseasesAls, FTDALS1
Known Drugs/Compoundsrapamycin
InteractionsC9ORF72, FLCN, AMYOTROPHIC LATERAL SCLEROSIS, AUTOPHAGY, ALS, DEMENTIA
KG Connections67 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Autophagosome Maturation Checkpoint Control
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Wilson Disease Neurodegeneration: Mechanism and Therapeutic
clinical · proposed · Score: 0.40

See Also (10)

Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
ULK1 — UNC-51 Like Kinase 1
gene · KG edge: associated_with
SMCR8 Gene
gene · KG edge: interacts_with
FLCN Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

WDR41 associated_with ULK1
WDR41 interacts_with C9ORF72
WDR41 interacts_with FLCN
WDR41 interacts_with SMCR8
WDR41 inhibits cell_viability
WDR41 inhibits cell_migration
WDR41 associated_with FTDALS1
WDR41 activates neurodegeneration
WDR41 interacts_with AMYOTROPHIC LATERAL SCLEROSIS
WDR41 associated_with AUTOPHAGY