Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CEREBELLUM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CEREBELLUM |
| Key Genes/Proteins | TARDBP |
| Related Diseases | ALS, PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, CHOLESTEROL, SUPEROXIDE |
Knowledge base pages for this entity
graph TD
CEREBELLUM["CEREBELLUM"]
CEREBELLUM -->|"interacts"| Purkinje_Cell["Purkinje Cell"]
CEREBELLUM -->|"expressed in"| PURKINJE["PURKINJE"]
CEREBELLUM -->|"causes"| TUMOR["TUMOR"]
Purkinje_Cell -->|"inhibits"| CEREBELLUM
ATP["ATP"] -->|"expressed in"| CEREBELLUM
DRP1["DRP1"] -->|"expressed in"| CEREBELLUM
PRKAA1["PRKAA1"] -->|"expressed in"| CEREBELLUM
JUN["JUN"] -->|"expressed in"| CEREBELLUM
NRF1["NRF1"] -->|"expressed in"| CEREBELLUM
OPA1["OPA1"] -->|"expressed in"| CEREBELLUM| Target | Relation | Type | Str |
|---|---|---|---|
| NEURON | expressed_in | cell_type | 0.95 |
| PURKINJE CELLS | expressed_in | cell_type | 0.80 |
| CORTEX | expressed_in | brain_region | 0.80 |
| CORTEX | accumulates_in | brain_region | 0.65 |
| SPINAL CORD | accumulates_in | brain_region | 0.65 |
| HIPPOCAMPUS | expressed_in | brain_region | 0.65 |
| NEURON | contributes_to | cell_type | 0.65 |
| NEURONS | contributes_to | cell_type | 0.65 |
| SUPEROXIDE | causes | phenotype | 0.65 |
| PURKINJE | expressed_in | cell_type | 0.60 |
| TUMOR | causes | disease | 0.60 |
| GABAERGIC | promotes | cell_type | 0.60 |
| PINK1 | expressed_in | gene | 0.60 |
| FTD | contributes_to | disease | 0.60 |
| STING | expressed_in | gene | 0.60 |
| PURKINJE | activates | cell_type | 0.60 |
| PURKINJE | causes | cell_type | 0.60 |
| C9orf72 | implicated_in | gene | 0.55 |
| C9orf72 | participates_in | gene | 0.55 |
| AGING | implicated_in | phenotype | 0.55 |
| PLCG2 | expressed_in | gene | 0.55 |
| CORTEX | co_discussed | entity | 0.50 |
| STRIATUM | co_discussed | entity | 0.50 |
| THALAMUS | co_discussed | entity | 0.50 |
| WHITE MATTER | co_discussed | entity | 0.50 |
| PURKINJE | co_discussed | entity | 0.50 |
| CEREBRAL CORTEX | expressed_in | brain_region | 0.50 |
| THALAMUS | expressed_in | brain_region | 0.50 |
| PURKINJE CELLS | implicated_in | cell_type | 0.50 |
| CORTEX | regulates | brain_region | 0.50 |
| CORTEX | inhibits | brain_region | 0.50 |
| HIPPOCAMPUS | activates | brain_region | 0.50 |
| CEREBRAL CORTEX | associated_with | concept | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| SGMS1 | expressed_in | concept | 0.50 |
| FRONTAL | associated_with | concept | 0.50 |
| ENTORHINAL CORTEX | associated_with | concept | 0.50 |
| FCGRT | associated_with | concept | 0.50 |
| SYNCRIP | expressed_in | concept | 0.50 |
| PREFRONTAL CORTEX | associated_with | concept | 0.50 |
| AMYGDALA | activates | concept | 0.50 |
| TREM2 | associated_with | gene | 0.50 |
| FGFR1 | associated_with | gene | 0.50 |
| VEGF | associated_with | gene | 0.50 |
| MITOPHAGY | associated_with | phenotype | 0.45 |
| MICROGLIA | associated_with | cell_type | 0.45 |
| ATM | associated_with | gene | 0.45 |
| ROS | associated_with | phenotype | 0.45 |
| PINK1 | associated_with | gene | 0.45 |
| OPA1 | associated_with | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS | associated_with | disease | 0.90 |
| PARKINSON'S DISEASE | associated_with | disease | 0.82 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.72 |
| CHOLESTEROL | produces | phenotype | 0.70 |
| CHOLESTEROL | destabilizes | phenotype | 0.70 |
| TARDBP | associated_with | gene | 0.66 |
| ATAXIA | reduces | disease | 0.65 |
| OLIGODENDROCYTES | protects_against | cell_type | 0.65 |
| SCHIZOPHRENIA | interacts_with | disease | 0.65 |
| MAPT | encodes | gene | 0.65 |
| ALS | contributes_to | disease | 0.60 |
| C9ORF72 | contributes_to | gene | 0.60 |
| APOPTOSIS | inhibits | process | 0.58 |
| ASTROCYTES | expressed_in | cell_type | 0.58 |
| AMPK | activates | gene | 0.58 |
| JUN | associated_with | gene | 0.56 |
| AMYLOID | associated_with | protein | 0.56 |
| BDNF | associated_with | gene | 0.56 |
| LAMP2 | expressed_in | gene | 0.55 |
| AUTOPHAGY | expressed_in | phenotype | 0.55 |
| ASTROCYTES | activates | cell_type | 0.50 |
| Cortex | associated_with | brain_region | 0.50 |
| STRIATUM | associated_with | concept | 0.50 |
| White Matter | associated_with | process | 0.50 |
| THALAMUS | associated_with | concept | 0.50 |
| Spinal Cord | associated_with | cell_type | 0.50 |
| MITOCHONDRIA | inhibits | cell_type | 0.50 |
| apoptosis | inhibits | process | 0.50 |
| mitophagy | inhibits | pathway | 0.50 |
| Mitochondrial Function | inhibits | pathway | 0.50 |
| Ataxia | inhibits | disease | 0.50 |
| Hippocampus | expressed_in | entity | 0.50 |
| Neuroinflammation | activates | process | 0.50 |
| inflammation | activates | pathway | 0.50 |
| MLCK | activates | gene | 0.50 |
| NADPH | activates | protein | 0.50 |
| OCCLUDIN | activates | protein | 0.50 |
| microglia | activates | cell_type | 0.50 |
| Astrocytes | expressed_in | cell_type | 0.50 |
| Cortex | expressed_in | brain_region | 0.50 |
| NEURONS | expressed_in | concept | 0.50 |
| Hippocampus | associated_with | entity | 0.50 |
| Neurodegeneration | activates | disease | 0.50 |
| Neurodegenerative Diseases | activates | disease | 0.50 |
| disease | activates | disease | 0.50 |
| Ampk Signaling | activates | pathway | 0.50 |
| Cortex | regulates | brain_region | 0.50 |
| SCHIZOPHRENIA | expressed_in | disease | 0.50 |
| THALAMUS | expressed_in | concept | 0.50 |
| HYPOTHALAMUS | expressed_in | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||