gene 1,145 words KG: APAF1 2026-03-27
kind:genesection:genesstate:published
Contents

APAF1 Gene

🧬 Gene Info
Gene SymbolAPAF1
Full NameAPAF1
AliasesApoptotic Protease-Activating Factor 1
Protein TypeGene
Functionis a critical regulator of the intrinsic (mitochondrial) apoptosis pathway.
Molecular Weight130 kDa
Pathwaysapoptosis
NCBI Gene IDSearch NCBI
GeneCardsAPAF1
Human Protein AtlasAPAF1
Associated Diseasesneurodegenerative_diseases
InteractionsTXNIP, Rb, AND, APOPTOSIS, AMPK, IL-1B
KG Connections62 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

APAF1 activates TXNIP
APAF1 regulates TBK1
APAF1 activates caspase-9
APAF1 activates caspase-3
APAF1 participates_in axon_degeneration
APAF1 implicated_in neurodegenerative_diseases
APAF1 regulates CASPASE3
APAF1 regulates BECLIN1
APAF1 regulates ATG5
APAF1 regulates BAX