protein

CASPASE-9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE-9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

9Outgoing

8Incoming

0Experiments

0Debates

Summary

Page for Caspase-9

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🔬 Protein Info

Gene Symbol	CASPASE
GeneCards	CASPASE
Human Protein Atlas	CASPASE
Associated Diseases	Fibrosis, Cancer, Als, Aging, Lymphoma, Neurodegeneration
Interactions	BCL2, CASPASE-3, IL-1Β
KG Connections	16 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    CASPASE_9["CASPASE-9"]
    CASPASE_9 -->|"activates"| IL_1_["IL-1Beta"]
    CASPASE_9 -->|"activates"| inflammation["inflammation"]
    CASPASE_9 -->|"activates"| apoptosis["apoptosis"]
    CASPASE_9 -->|"activates"| Hippocampus["Hippocampus"]
    CASPASE_9 -->|"expressed in"| NF__B_P65["NF-KappaB P65"]
    CASPASE_9 -->|"expressed in"| NF__B["NF-kappaB"]
    CASPASE_9 -->|"expressed in"| BCL_2["BCL-2"]
    APAF1["APAF1"] -->|"activates"| CASPASE_9
    BCL2["BCL2"] -->|"activates"| CASPASE_9
    CASPASE_3["CASPASE-3"] -->|"activates"| CASPASE_9
    GFAP["GFAP"] -->|"expressed in"| CASPASE_9
    CYTC["CYTC"] -->|"expressed in"| CASPASE_9
    IL_6["IL-6"] -->|"expressed in"| CASPASE_9

Outgoing (9)

Target	Relation	Type	Str
IL-1Β	activates	protein	0.50
inflammation	activates	pathway	0.50
apoptosis	activates	process	0.50
Hippocampus	activates	entity	0.50
IL-1Β	expressed_in	protein	0.50
NF-ΚB P65	expressed_in	protein	0.50
NF-κB	expressed_in	concept	0.50
BCL-2	expressed_in	protein	0.50
TNF-α	expressed_in	concept	0.50

Incoming (8)

Source	Relation	Type	Str
APAF1	activates	protein	0.80
CASPASE-3	associated_with	protein	0.50
BCL2	activates	gene	0.50
CASPASE-3	activates	protein	0.50
GFAP	expressed_in	gene	0.50
CYTC	expressed_in	gene	0.50
CASPASE-3	expressed_in	protein	0.50
IL-6	expressed_in	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity