TXNIP

Understanding Entity Pages

This page aggregates everything SciDEX knows about TXNIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TXNIP is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with Als, Atherosclerosis, Diabetes. Connected to 65 entities in the SciDEX knowledge graph.

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graph TD
    TXNIP["<b>TXNIP</b>"]
    PRKAA["PRKAA"]
    TXNIP -->|"interacts with"| PRKAA
    TXNIP -->|"regulates"| PRKAA
    autophagy(["autophagy"])
    TXNIP -->|"activates"| autophagy
    fatty_acid_oxidation(["fatty acid oxidation"])
    TXNIP -->|"activates"| fatty_acid_oxidation
    steatohepatitis{"steatohepatitis"}
    TXNIP -->|"protects against"| steatohepatitis
    Atherosclerosis{"Atherosclerosis"}
    TXNIP -->|"activates"| Atherosclerosis
    Stroke{"Stroke"}
    TXNIP -->|"activates"| Stroke
    Hepatitis{"Hepatitis"}
    TXNIP -->|"inhibits"| Hepatitis
    Diabetes{"Diabetes"}
    TXNIP -->|"therapeutic target"| Diabetes
    Fibrosis{"Fibrosis"}
    TXNIP -->|"activates"| Fibrosis
    Inflammation{"Inflammation"}
    TXNIP -->|"activates"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    TXNIP -->|"activates"| Neuroinflammation
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"activates"| TXNIP
    LC3B["LC3B"]
    LC3B -->|"activates"| TXNIP
    P62["P62"]
    P62 -->|"activates"| TXNIP
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"activates"| TXNIP
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| TXNIP
    STING["STING"]
    STING -->|"activates"| TXNIP
    GENES["GENES"]
    GENES -->|"activates"| TXNIP
    NRF2["NRF2"]
    NRF2 -->|"activates"| TXNIP
    CYLD["CYLD"]
    CYLD -->|"activates"| TXNIP
    APAF1["APAF1"]
    APAF1 -->|"activates"| TXNIP
    MTORC1["MTORC1"]
    MTORC1 -->|"activates"| TXNIP
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| TXNIP
    style TXNIP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0