protein

CASPASE-3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE-3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

132Connections

0Hypotheses

0Analyses

50Outgoing

40Incoming

Summary

Page for Caspase-3 Protein

View on Wiki →

🔬 Protein Info

Gene Symbol	CASPASE
GeneCards	CASPASE
Human Protein Atlas	CASPASE
Associated Diseases	Fibrosis, Cancer, Als, Aging, Lymphoma, Neurodegeneration
Interactions	AMYLOID, HES1, GASDERMIN E, GASDERMIN, NADPH, PUMA
KG Connections	116 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: CASPASE-3 — AlphaFold P42574 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CASPASE_3["<b>CASPASE-3</b>"]
    GSDME["GSDME"]
    CASPASE_3 -->|"cleaves"| GSDME
    AMYLOID["AMYLOID"]
    CASPASE_3 -->|"activates"| AMYLOID
    HES1["HES1"]
    CASPASE_3 -->|"activates"| HES1
    CD68["CD68"]
    CASPASE_3 -->|"expressed in"| CD68
    cancer["cancer"]
    CASPASE_3 -->|"expressed in"| cancer
    TUMOR["TUMOR"]
    CASPASE_3 -->|"expressed in"| TUMOR
    Macrophage["Macrophage"]
    CASPASE_3 -->|"expressed in"| Macrophage
    MACROPHAGES["MACROPHAGES"]
    CASPASE_3 -->|"expressed in"| MACROPHAGES
    apoptosis["apoptosis"]
    CASPASE_3 -->|"inhibits"| apoptosis
    cancer["cancer"]
    CASPASE_3 -->|"activates"| cancer
    Pyroptosis["Pyroptosis"]
    CASPASE_3 -->|"activates"| Pyroptosis
    BREAST_CANCER["BREAST CANCER"]
    CASPASE_3 -->|"activates"| BREAST_CANCER
    GASDERMIN_E["GASDERMIN E"]
    CASPASE_3 -->|"activates"| GASDERMIN_E
    TUMOR["TUMOR"]
    CASPASE_3 -->|"activates"| TUMOR
    CELL_DEATH["CELL DEATH"]
    CASPASE_3 -->|"activates"| CELL_DEATH
    METASTASIS["METASTASIS"]
    CASPASE_3 -->|"activates"| METASTASIS
    GASDERMIN["GASDERMIN"]
    CASPASE_3 -->|"activates"| GASDERMIN
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    CASPASE_3 -->|"activates"| Reactive_Oxygen_Species
    NADPH["NADPH"]
    CASPASE_3 -->|"activates"| NADPH
    PUMA["PUMA"]
    CASPASE_3 -->|"activates"| PUMA
    FIS1["FIS1"]
    CASPASE_3 -->|"activates"| FIS1
    BECLIN1["BECLIN1"]
    CASPASE_3 -->|"activates"| BECLIN1
    HO_1["HO-1"]
    CASPASE_3 -->|"activates"| HO_1
    inflammation["inflammation"]
    CASPASE_3 -->|"activates"| inflammation
    apoptosis["apoptosis"]
    CASPASE_3 -->|"activates"| apoptosis
    oxidative_stress["oxidative stress"]
    CASPASE_3 -->|"activates"| oxidative_stress
    BCL_2["BCL-2"]
    CASPASE_3 -->|"activates"| BCL_2
    Toll_Like_Receptor["Toll-Like Receptor"]
    CASPASE_3 -->|"activates"| Toll_Like_Receptor
    Lymphoma["Lymphoma"]
    CASPASE_3 -->|"activates"| Lymphoma
    ENDOTHELIAL["ENDOTHELIAL"]
    CASPASE_3 -->|"activates"| ENDOTHELIAL

Outgoing (82)

Target	Relation	Type	Str
AMYLOID	activates	gene	0.50
HES1	activates	gene	0.50
CD68	expressed_in	protein	0.50
cancer	expressed_in	disease	0.50
TUMOR	expressed_in	disease	0.50
Macrophage	expressed_in	cell_type	0.50
MACROPHAGES	expressed_in	concept	0.50
apoptosis	inhibits	process	0.50
cancer	activates	disease	0.50
Pyroptosis	activates	pathway	0.50
BREAST CANCER	activates	disease	0.50
GASDERMIN E	activates	protein	0.50
TUMOR	activates	disease	0.50
CELL DEATH	activates	concept	0.50
GASDERMIN	activates	gene	0.50
Reactive Oxygen Species	activates	process	0.50
NADPH	activates	protein	0.50
PUMA	activates	protein	0.50
FIS1	activates	protein	0.50
BECLIN1	activates	gene	0.50
HO-1	activates	protein	0.50
inflammation	activates	pathway	0.50
apoptosis	activates	process	0.50
oxidative stress	activates	phenotype	0.50
BCL-2	activates	protein	0.50
Toll-Like Receptor	activates	pathway	0.50
Lymphoma	activates	disease	0.50
ENDOTHELIAL	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
Sepsis	activates	disease	0.50
IL-17	activates	concept	0.50
Epithelial Cell	activates	cell_type	0.50
CASPASE-9	associated_with	protein	0.50
apoptosis	regulates	process	0.50
Jak-Stat	regulates	pathway	0.50
NEURONS	associated_with	concept	0.50
NLRP1	interacts_with	protein	0.50
BCL-2	interacts_with	protein	0.50
CYTOKINES	interacts_with	concept	0.50
Lymphoma	interacts_with	disease	0.50
RAPAMYCIN	interacts_with	concept	0.50
CASPASE-8	activates	protein	0.50
apoptosis	interacts_with	process	0.50
NEURONS	interacts_with	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
BCL-2	regulates	protein	0.50
Proteins	regulates	protein	0.50
HIF-1Α	activates	protein	0.50
NEURONS	regulates	concept	0.50
CASPASE-9	activates	protein	0.50

Incoming (50)

Source	Relation	Type	Str
AKT	activates	protein	0.50
CATALASE	activates	protein	0.50
ALZHEIMER	activates	gene	0.50
PRESENILIN	activates	protein	0.50
ANXA1	expressed_in	protein	0.50
CASP3	expressed_in	gene	0.50
GSDME	activates	gene	0.50
STAT3	activates	gene	0.50
Pi3K	activates	pathway	0.50
Autophagy	activates	process	0.50
TAAR1	activates	gene	0.50
TRAF6	activates	gene	0.50
mTOR	activates	entity	0.50
SIGMAR1	activates	gene	0.50
MYD88	activates	gene	0.50
VEGF	activates	gene	0.50
CHOP	activates	gene	0.50
BCL2	activates	gene	0.50
NRF2	activates	gene	0.50
CREB	activates	protein	0.50
S100A9	activates	gene	0.50
Neurodegeneration	regulates	disease	0.50
GLAUCOMA	associated_with	gene	0.50
JAK2	activates	gene	0.50
Pi3K	interacts_with	pathway	0.50
BDNF	interacts_with	gene	0.50
TRKB	interacts_with	gene	0.50
mTOR	interacts_with	entity	0.50
BCL2	interacts_with	gene	0.50
CHMP4B	activates	gene	0.50
CHMP4B	interacts_with	gene	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
MITOCHONDRIA	regulates	cell_type	0.50
GFAP	expressed_in	gene	0.50
CYTC	expressed_in	gene	0.50
PSEN1	activates	gene	0.50
HES1	activates	gene	0.50
NMNAT1	inhibits	gene	0.50
Neurodegeneration	activates	disease	0.50
mTOR	inhibits	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CASPASE-3

Understanding Entity Pages

Summary

Wiki Pages (20)

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Pannexin 1 and P2X7 Receptor Signaling in Neurodegeneration

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CNTF Signaling Pathway in Neurodegeneration

Synaptic Plasticity Deficits in Neurodegeneration

TGF-β Signaling in Parkinson's Disease

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