| Gene Symbol | ATG5 |
| Chromosome | 6q21 |
| Function | ATG5 is central to autophagy: - Autophagosome formation: Essential for the expansion and closure of the autophagosome - ATG12-ATG5-ATG16L1 complex: Functions as an E3-like enzyme for LC3 lipidation - |
| Molecular Weight | ~32 kDa |
| Pathways | AUTOPHAGY_PATHWAY, Autophagy, Camp Signaling, Chaperone, Chemoresistance |
| GeneCards | ATG5 |
| Human Protein Atlas | ATG5 |
| Approach | Mechanism |
| Autophagy enhancers | Research |
| ATG5 expression | Research |
| Small molecule activators | Preclinical |
| Autophagy inducers | mTOR inhibition |
| ATG5 modulators | Expression control |
| Small molecule enhancers | Core autophagy |
| Associated Diseases | AD, ALS, AMI, ARM, Ataxia |
| Known Drugs/Compounds | CURCUMIN, curcumin, nicotinamide, statins, rapamycin, RAPAMYCIN |
| Interactions | EIF4EBP1, LC3, MTOR, ABCG1, SQSTM1, ABCA1 |
| KG Connections | 1675 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |