protein 1,419 words KG: BECLIN1 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

Beclin-1

🔬 Protein Info
Gene SymbolBECLIN1
Full NameBECN1
Chromosome17q21.31
Protein FamilyAtg6/Beclin family
Protein TypeGene
Functionis a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis
Subcellular LocalizationER, mitochondria, trans-Golgi network, endosomes
Molecular Weight~52 kDa
Amino Acids450
PathwaysApoptosis, Autophagy, Mtor, Oxidative Stress
UniProt IDQ14457
GeneCardsBECLIN1
Human Protein AtlasBECLIN1
GeneBECN1
Associated DiseasesAls, Alzheimer, Cancer, Colorectal Cancer, Glioblastoma, Inflammation
InteractionsMTOR, SOX9, AKT, RANK, RANKL, BCL2
KG Connections623 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (25)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Closed-loop tACS targeting entorhinal cortex layer II SST in
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.61
Autophagosome Maturation Checkpoint Control
Score: 0.49
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (3)

CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

Alzheimer Indonesia
institution · KG edge: associated_with
APAF1 Gene
gene · KG edge: regulates
AMBRA1 Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

BECLIN1 associated_with BCL2
BECLIN1 associated_with TAAR1
BECLIN1 associated_with SIGMAR1
BECLIN1 associated_with MYD88
BECLIN1 associated_with PUMA
BECLIN1 associated_with P62
BECLIN1 activates MTOR
BECLIN1 activates SOX9
BECLIN1 activates AKT
BECLIN1 associated_with LC3