protein 1,226 words KG: BAX 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

BAX Protein

🔬 Protein Info
Gene SymbolBAX
Chromosome19q13.33
Protein FamilyBCL-2 family (BH3-only pro-apoptotic)
Functionis a critical pro-apoptotic member of the BCL-2 protein family that plays a central role in regulating mitochondrial apoptosis.
Subcellular LocalizationCytosol (inactive), Mitochondria (active), ER
Molecular Weight21 kDa (192 amino acids)
Amino Acids192 aa
PathwaysAkt, Apoptosis, Autophagy, Cell Division, Cholesterol
UniProt IDQ07812
Ensembl IDENSG00000087088
GeneCardsBAX
Human Protein AtlasBAX
Associated DiseasesALS, Aging, Alzheimer, Ataxia, Cancer
Known Drugs/CompoundsRAPAMYCIN, CISPLATIN, BERBERINE, cadmium, magnolol, Tirzepatide
InteractionsJUN, ALOX15, GSDMD, SCD1, HMGCR, TNF
KG Connections2330 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (4)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
AIFM1 Gene
gene · KG edge: expressed_in
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: associated_with
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activates

Knowledge Graph (12 edges)

BAX associated_with EHMT2
BAX inhibits JUN
BAX associated_with FOXO1
BAX associated_with BCL2
BAX inhibits ALOX15
BAX inhibits GSDMD
BAX inhibits SCD1
BAX inhibits HMGCR
BAX inhibits TNF
BAX inhibits MLKL