gene 2,401 words KG: ARRB2 2026-03-27
kind:genesection:genesstate:published
Contents

ARRB2 — Arrestin Beta 2

🧬 Gene Info
Gene SymbolARRB2
Full NameArrestin Beta 2
AliasesARR2, BARR2, Beta-Arrestin-2
Chromosome17p13.1
Protein TypeBeta-arrestin (Scaffold Protein)
Functionis a member of the arrestin family of proteins that plays critical roles in regulating G protein-coupled receptor (GPCR) signaling, receptor internalization, and downstream signal transduction.
Molecular Weight~46 kDa
Amino Acids409 aa
PathwaysMAPK, PI3K, NF-ÎșB pathway, MAPK pathway
UniProt IDP35610
NCBI Gene ID410
GeneCardsARRB2
Human Protein AtlasARRB2
Gene NameArrestin Beta 2
Protein Size409 amino acids
Associated Diseasesneurodegeneration
InteractionsNLRP3, TLR, SAMD4, TLR4, CASP1, IL1B
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

ARRB2 regulates SORLA
ARRB2 interacts_with SAMD4
ARRB2 interacts_with NLRP3
ARRB2 modulates NLRP3
ARRB2 modulates Anti-Inflammatory Reactivity
ARRB2 regulates SAMD4
ARRB2 activates NLRP3
ARRB2 associated_with ATP1A3
ARRB2 associated_with GLUD1
ARRB2 causes BIN1