| Gene Symbol | ALPHASYNUCLEIN |
| Aliases | ALPHASYNUCLEIN |
| Synaptic regulation | Modulates synaptic vesicle pools and neurotransmitter release |
| Dopamine metabolism | Influences tyrosine hydroxylase activity |
| Antioxidant activity | May protect neurons from oxidative stress |
| Chaperone activity | Involved in protein folding and degradation[@spillantini1997] |
| SNCA Multiplications | Duplications/triplications cause familial PD |
| Point Mutations | A53T, A30P, E46K cause familial synucleinopathy |
| SNP Variants | Risk variants in the SNCA promoter affect expression |
| Elevated in PD/DLB | >90% of PD patients show elevated p-Ser129 |
| Correlates with disease severity | Higher levels with more advanced disease |
| Diagnostic utility | Helps differentiate PD from non-synucleinopathies[@fujiwara2002] |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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