biomarker 1,155 words KG: ALZHEIMERS
Contents

Digital Biomarkers for Alzheimer's Disease

🔬 Protein Info
Gene Symbolalzheimers
Aliasesalzheimers
Walking speedSlower gait velocity correlates with cognitive decline and progression to dementia[@schon2018]
Stride length variabilityIncreased variability in step length and time is associated with mild cognitive impairment (MCI) and early AD[@muurling2021]
Swing/stance ratioChanges in the proportion of time spent in swing versus stance phase
Dual-task costGait degradation during simultaneous cognitive tasks is more pronounced in AD patients[@muirhunter2014]
Sleep efficiencyReduced sleep efficiency correlates with amyloid burden[@spira2017]
Total sleep timeIncreased nocturnal wakefulness and fragmented sleep in early AD[@bokenberger2018]
Circadian rhythm amplitudeWeakened circadian patterns associated with disease severity[@videnovic2014]
Activity levelsLower daytime activity and increased sedentary behavior[@naska2017]
Digit symbol substitutionTouchscreen-based processing speed tests[@kaye2014]
Picture vocabularyLanguage assessment through image recognition tasks[@rentz2016]
Spatial memoryGrid-based memory tasks measuring episodic memory[@wojtalik2018]
Typing dynamicsAnalysis of keystroke timing patterns as proxy for fine motor control and cognition[@giancardo2016]
Acoustic featuresSpeech rate, pause duration, pitch variation, and voice quality[@knig2015]
Linguistic contentWord retrieval difficulty, repetition, and semantic coherence[@fraser2016]
Associated DiseasesALZHEIMER
KG Connections7 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (28)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.83
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.83
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
TREM2-mediated microglial tau clearance enhancement
Score: 0.80
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78

Related Analyses (21)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.95
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40

See Also (15)

ASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Astrocyte-Derived Exosomal mRNA Reference Genes for Alz
biomarker · Pages share 18 hypotheses
AT(N) Biomarker Classification for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
A/T/N+ Comprehensive Biomarker Panel for Alzheimer's Di
biomarker · Pages share 18 hypotheses
Blood p-Tau217 as a Clock for Alzheimer's Disease Onset
mechanism · Pages share 18 hypotheses

Knowledge Graph (6 edges)

TREM2 associated_with ALZHEIMERS
SERPINA3N associated_with ALZHEIMERS
ALZHEIMERS activates WAM
R47H_TREM2 contributes_to ALZHEIMERS
DAM associated_with ALZHEIMERS
MICROGLIA participates_in ALZHEIMERS

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