biomarker 1,742 words KG: astrocyte 2026-03-25
kind:biomarkersection:biomarkersstate:publishedtopic:alzheimers
Contents

Astrocyte-Derived Exosomal mRNA Reference Genes for Alzheimer's Disease

🔬 Protein Info
Gene Symbolastrocyte
Cerebrospinal fluid (CSF)Highest astrocyte-specific exosome concentration, closest to CNS
Blood (plasma/serum)Less invasive, moderate astrocyte exosome abundance
Brain tissueResearch use only, most direct assessment of CNS pathology
Primary combinationACTB + RPL13A (highest stability)
Alternative combinationGUSB + PPIA (excellent for blood samples)
Comprehensive panelACTB + RPL13A + GUSB (optimal for most studies)
Associated DiseasesAlzheimer's disease, Multiple sclerosis
KG Connections45 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (30)

Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.46
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.46
Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.95
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.46

See Also (15)

Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 18 hypotheses
Ubiquitin-Proteasome System Dysfunction in Alzheimer's
mechanism · Pages share 18 hypotheses
Tau Kinase Signaling Cascade in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Tau Kinase-Phosphatase Balance in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Synaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 18 hypotheses

Knowledge Graph (12 edges)

astrocyte associated_with Multiple sclerosis
astrocyte associated_with neuron
astrocyte interacts_with neuron
astrocyte involved_in neurodegenerative stress response
astrocyte involved_in Temporal Lobe Epilepsy
astrocyte associated_with Alzheimer's disease
astrocyte implicated_in Alzheimer's disease
astrocyte co_discussed lysosome
MAP1LC3B expressed_in astrocyte
CB2R expressed_in astrocyte