biomarker 1,137 words KG: ALZHEIMERS 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

Ocular Fluid Biomarkers for Alzheimer's Disease

🔬 Protein Info
Gene Symbolalzheimers
Aliasesalzheimers
Aqueous humorClear fluid in the anterior chamber (between cornea and lens)
Vitreous humorGel-like substance filling the posterior chamber (behind lens, before retina)
AD finding1.8-2.5 fold increase
Sensitivity70-78%
Specificity68-75%
CorrelationCorrelates with cognitive decline (MMSE r=-0.58)
NoteLess AD-specific than p-Tau, elevated in other neurodegenerative conditions
Associated DiseasesALZHEIMER
KG Connections7 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (29)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.83
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.83
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
TREM2-mediated microglial tau clearance enhancement
Score: 0.80
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78

Related Analyses (22)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (30)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

TREM2 Agonist Therapies for Alzheimer's Disease
therapeutic · Pages share 18 hypotheses
Tau Immunotherapy for Alzheimer's Disease
therapeutic · Pages share 18 hypotheses
Sodium Oligomannate (GV-971) for Alzheimer's Disease
therapeutic · Pages share 18 hypotheses
Siponimod for Alzheimer's Disease
therapeutic · Pages share 18 hypotheses
Nanomedicine Approaches to Alzheimer's Disease
therapeutic · Pages share 18 hypotheses

Knowledge Graph (6 edges)

ALZHEIMERS activates WAM
TREM2 associated_with ALZHEIMERS
SERPINA3N associated_with ALZHEIMERS
R47H_TREM2 contributes_to ALZHEIMERS
DAM associated_with ALZHEIMERS
MICROGLIA participates_in ALZHEIMERS

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