biomarker 1,019 words KG: DNA 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

DNA Methylation Biomarkers in Neurodegeneration

🔬 Protein Info
Gene SymbolDNA
Functionis an epigenetic modification that regulates gene expression without changing the DNA sequence.
PathwaysAMPK signaling, Adaptive Immunity, Akt, Amyloid, Angiogenesis
GeneCardsDNA
Human Protein AtlasDNA
Biomarker TypeEpigenetic (DNA modification)
TargetCpG sites across the genome
Sample TypesBlood, Brain tissue, CSF
Detection MethodBisulfite sequencing, EPIC array, Methylation arrays
Key SitesHorvath clock sites, PHD1, ELOVL2
Associated DiseasesAD, ALI, ALS, AMI, ARM, Addiction
Known Drugs/Compoundsrapamycin, metformin, ketamine, valproic acid, resveratrol
InteractionsMAPT, FAS, PEN2, APH1B, PSEN1, TARDBP
KG Connections5631 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.88
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.86
Transcriptional Autophagy-Lysosome Coupling
Score: 0.86
CYP46A1 Overexpression Gene Therapy
Score: 0.84

Related Analyses (30)

Epigenetic reprogramming in aging neurons
neurodegeneration · completed
How do dilncRNAs specifically drive molecular crowding and p
neurodegeneration · completed
What determines the specificity of DDR protein recruitment t
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (30)

GWAS of plasma pTau217 in East Asian cohort
exploratory · proposed · Score: 0.95
Single-cell RNA-seq analysis of mouse testes with gonadal de
exploratory · proposed · Score: 0.95
cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95
Factor depletion effects on DDR focus formation in vivo
exploratory · proposed · Score: 0.90
Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses

Knowledge Graph (12 edges)

DNA associated_with APOE
DNA associated_with Cardiovascular
DNA associated_with AMPK
DNA associated_with PINK1
DNA associated_with Mitophagy
DNA associated_with PTEN
DNA associated_with RB1
DNA associated_with STAT3
DNA associated_with Mapk
DNA associated_with Neuroinflammation