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cell 1,770 words KG: synaptic_loss
Contents

Synaptic Loss in Neurodegeneration

🧫 Cell Type Info
Cell Typesynaptic_loss
Related GenesAPOE4 fragments, C1q, soluble_tau_oligomers, SPP1
Linked Hypotheses15 hypotheses

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (150)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE-TREM2 Interaction Modulation
Score: 0.74TREM2-Dependent Microglial Senescence Transition
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54...
Score: 0.68APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.65Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61
← Prevpg 8/8

Related Analyses (30)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · completedCell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archivedCell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archivedCell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archivedSenescent cell clearance as neurodegeneration therapy
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (12 edges)

phagocytosis causes synaptic_loss
mechanisms-synaptic-loss-ad describes synaptic_loss
tripartite_synapse_dysfunction causes synaptic_loss
complement_cascade causes synaptic_loss
Alzheimer's_disease causes synaptic_loss
tripartite_synapse_dysfunction NULL synaptic_loss
synaptic_loss associated_with alzheimers
synaptic_loss causes Cognitive decline
synaptic_loss associated_with Cognitive decline
soluble_tau_oligomers causes synaptic_loss

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