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cell 970 words KG: MICROGLIA
Contents

Synaptic Pruning Microglia

🧫 Cell Type Info
Cell TypeMICROGLIA
Also Known AsMicroglial cells, Brain-resident macrophages
DefinitionResident immune cells of the central nervous system derived from yolk sac progenitors
FunctionsImmune surveillance, Synaptic pruning, Phagocytosis, Cytokine production, Debris clearance
Key MarkersIBA1, CD11b, CX3CR1, P2RY12, TMEM119, TREM2
StatesHomeostatic, Disease-associated (DAM), Activated, Phagocytic, Senescent
Key PathwaysTREM2-DAP12 signaling, TLR4-NF-kB, CSF1R signaling, Complement cascade, cGAS-STING
Associated DiseasesAlzheimer's disease, Parkinson's disease, Multiple sclerosis, ALS, Nasu-Hakola disease
DiscoveryFirst described by Pío del Río Hortega in 1919
Linked Hypotheses294 hypotheses

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Knowledge Graph

Related Hypotheses (30)

Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68TREM2-mediated microglial tau clearance enhancement
Score: 0.80Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.74Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66TREM2-Dependent Microglial Senescence Transition
Score: 0.95

Related Analyses (23)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedGene expression changes in aging mouse brain predicting neur
neurodegeneration · archived

Related Experiments (7)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.40TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40Sex Differences in Alzheimer's Disease — mechanisms and ther
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

MICROGLIA associated_with ALZHEIMER'S_DISEASE
MICROGLIA interacts_with BDNF
MICROGLIA interacts_with CD22
MICROGLIA expresses TNF-α
MICROGLIA expresses IL-6
MICROGLIA expresses IL-1β
MICROGLIA expresses ACOD1
MICROGLIA disrupts GLOBE_TIO2_TDCPP_EXPOSURE
MICROGLIA associated_with CHILDHOOD_DEPRIVATION
MICROGLIA modulates SYNAPTIC_PRUNING

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