TMEM119

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM119: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TMEM119 gene page - highly specific microglial marker in the CNS involved in bone morphogenetic protein signaling and neurodegenerative disease

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graph TD
    TMEM119["<b>TMEM119</b>"]
    Neuroinflammation{"Neuroinflammation"}
    TMEM119 -->|"biomarker for"| Neuroinflammation
    Inflammation{"Inflammation"}
    TMEM119 -->|"biomarker for"| Inflammation
    Neurodegeneration{"Neurodegeneration"}
    TMEM119 -->|"biomarker for"| Neurodegeneration
    Dementia{"Dementia"}
    TMEM119 -->|"biomarker for"| Dementia
    Als{"Als"}
    TMEM119 -->|"biomarker for"| Als
    Alzheimer{"Alzheimer"}
    TMEM119 -->|"biomarker for"| Alzheimer
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    TMEM119 -->|"biomarker for"| Traumatic_Brain_Injury
    Parkinson{"Parkinson"}
    TMEM119 -->|"biomarker for"| Parkinson
    TMEM119 -->|"associated with"| Inflammation
    TMEM119 -->|"associated with"| Neuroinflammation
    TMEM119 -->|"activates"| Alzheimer
    ALS{"ALS"}
    TMEM119 -->|"biomarker for"| ALS
    UCHL1["UCHL1"]
    UCHL1 -->|"interacts with"| TMEM119
    GFAP["GFAP"]
    GFAP -->|"interacts with"| TMEM119
    P2RY12["P2RY12"]
    P2RY12 -->|"expressed in"| TMEM119
    NFL["NFL"]
    NFL -->|"interacts with"| TMEM119
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| TMEM119
    AMYLOID_BETA["AMYLOID-BETA"]
    AMYLOID_BETA -->|"activates"| TMEM119
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"biomarker for"| TMEM119
    ALZHEIMER_S_DISEASE -->|"biomarker for"| TMEM119
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"expressed in"| TMEM119
    AND["AND"]
    AND -->|"expressed in"| TMEM119
    GAIN["GAIN"]
    GAIN -->|"biomarker for"| TMEM119
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"biomarker for"| TMEM119
    style TMEM119 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0