| Gene Symbol | CFL1 |
| Function | Cofilin 1 is a small actin-binding protein (19 kDa) that promotes the disassembly and reassembly of actin filaments. |
| Molecular Weight | 19 kDa |
| Amino Acids | 166 aa |
| Pathways | Apoptosis |
| Ensembl ID | ENSG00000132716 |
| GeneCards | CFL1 |
| Human Protein Atlas | CFL1 |
| Actin Filament Turnover | Cofilin binds to aged or ADP-actin subunits within filaments, promoting their depolymerization and enabling rapid actin dynamics essential for cellular motility, endocytosis, and cytokinesis. |
| Neuronal Morphogenesis | In neurons, cofilin regulates actin dynamics in growth cones, dendritic spines, and axonal branches, influencing neuronal migration, axon guidance, and synapse formation. |
| Axonal Transport | The actin cytoskeleton provides tracks for myosin-based transport in regions where microtubules are sparse. Cofilin regulates this process in axons and dendrites. |
| Nuclear Functions | Cofilin can translocate to the nucleus where it may regulate gene expression and chromatin remodeling. |
| Associated Diseases | Als |
| Interactions | EFHD2 |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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