gene 670 words KG: LGALS1 2026-03-24
kind:genesection:genesstate:published
Contents

LGALS1 — Galectin-1

🧬 Gene Info
Gene SymbolLGALS1
Full NameGalectin-1
Chromosome22q13.1
FunctionLGALS1 performs diverse biological functions:
Amino Acids135 aa
PathwaysMapk
GeneCardsLGALS1
Human Protein AtlasLGALS1
Cell TypeExpression Level
[Neurons](/entities/neurons)High (specific subtypes)
[Astrocytes](/entities/astrocytes)High
[Microglia](/entities/microglia)Moderate
Schwann CellsHigh
Immune CellsVariable
ModelFindings
Associated DiseasesAls, Ms
InteractionsJAK2, GNB4, HSP90B1, EGFR, HSPA4, FOXO1
KG Connections89 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (23)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: activates
LAMB2 — Laminin Subunit Beta 2
gene · KG edge: activates
IGF1 Gene
gene · KG edge: activates
HSPA4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

LGALS1 associated_with CALCOCO2
LGALS1 associated_with CDKN1A
LGALS1 associated_with NPC1
LGALS1 associated_with P4HB
LGALS1 associated_with MT2A
LGALS1 expressed_in TERT
LGALS1 associated_with CFL1
LGALS1 expressed_in ATM
LGALS1 activates JAK2
LGALS1 regulates AKT