gene 2,193 words KG: TERT 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:aging
Contents

TERT Gene

🧬 Gene Info
Gene SymbolTERT
Full NameTelomerase Reverse Transcriptase
Chromosome5p15.33
Functiondyskerin (DKC1): Stabilizes the complex
Primary Expressionhippocampal subgranular zone (SGZ)
Molecular Weight127 kDa
Amino Acids1132 aa
Exons16
PathwaysTelomere Dysfunction
UniProt ID[O14748](https://www.uniprot.org/uniprot/O14748)
Ensembl IDENSG00000164362
OMIM607409
GeneCardsTERT
Human Protein AtlasTERT
Associated DiseasesAD, ALI, ALS, AMI, Cancer
Known Drugs/CompoundsTAC
InteractionsGJA1, ACVR2A, CTNNB1, TP53, NRF2, KEAP1
KG Connections550 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61

Related Analyses (19)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (14)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
AXIN1 Gene
gene · KG edge: therapeutic_target
ATRX — Alpha Thalassemia/Mental Retardation Syndrome X-
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TERT therapeutic_target JUN
TERT therapeutic_target EEF1A1
TERT therapeutic_target MCL1
TERT biomarker_for JUN
TERT associated_with CIC
TERT associated_with FUBP1
TERT associated_with H3F3A
TERT biomarker_for OVERVIEW
TERT associated_with BRAF
TERT associated_with ATRX