protein

ATM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1400Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

Summary

ATM is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 589 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATM
Full Name	Ataxia-Telangiectasia Mutated
Chromosome	11q22.3
Protein Type	Serine/Threonine Kinase
Function	is a PIKK-family serine/threonine kinase that coordinates genomic stress responses, especially after DNA double-strand breaks.
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Dna Damage Response
UniProt ID	[Q13315](https://www.uniprot.org/uniprotkb/Q13315)
Ensembl ID	ENSG00000149311
GeneCards	ATM
Human Protein Atlas	ATM
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compounds	mtDNA, rapamycin
Interactions	SNCAIP, RB1CC1, MFN1, ERN1, PARKIN, FMR1
KG Connections	1400 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATM["ATM"] -->|"expressed in"| synaptic_vesicles["synaptic vesicles"]
    ATM["ATM"] -->|"expressed in"| endosomes["endosomes"]
    ATM["ATM"] -->|"expressed in"| lysosomes["lysosomes"]
    ATM["ATM"] -->|"interacts"| ATR["ATR"]
    ATM["ATM"] -->|"interacts"| Dementia["Dementia"]
    ATM["ATM"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    CAT["CAT"] -->|"interacts"| ATM["ATM"]
    OPTN["OPTN"] -->|"interacts"| ATM["ATM"]
    DNM1L["DNM1L"] -->|"interacts"| ATM["ATM"]
    CANX["CANX"] -->|"interacts"| ATM["ATM"]
    style ATM fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (981)

Target	Relation	Type	Str
Cancer	activates	disease	1.00
Tumor	implicated_in	disease	0.90
Als	activates	disease	0.85
Tumor	inhibits	disease	0.85
Ataxia	activates	disease	0.85
Senescence	activates	disease	0.85
Inflammation	activates	disease	0.85
RFWD3	phosphorylates	gene	0.85
DLBCL	biomarker_for	disease	0.80
autophagy pathway	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
Ferroptosis	involved_in	process	0.80
mtDNA	modulates	compound	0.75
Mitochondrial dysfunction	associated_with	phenotype	0.75
Cancer	therapeutic_target	disease	0.75
Als	contributes_to	disease	0.75
Als	inhibits	disease	0.75
Cancer	associated_with	disease	0.75
Cancer	inhibits	disease	0.75
Aging	activates	disease	0.75
synaptic vesicles	expressed_in	cell_type	0.70
endosomes	expressed_in	cell_type	0.70
lysosomes	expressed_in	cell_type	0.70
ATR	interacts_with	protein	0.70
Autophagy-Lysosomal Pathway	regulates	biological_process	0.70
LC3	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
STING1	regulates	gene	0.70
ULK1	activates	gene	0.70
TDP-43	regulates	gene	0.70
TNF	inhibits	gene	0.70
TNF	stabilizes	gene	0.70
Ferroptosis	activates	pathway	0.70
Autophagy	activates	pathway	0.70
Apoptosis	activates	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Mapk	activates	pathway	0.70
Nf-Κb	activates	pathway	0.70
Dna Repair	activates	pathway	0.70
Dna Damage Response	involved_in	pathway	0.70
AUTOPHAGY	destabilizes	phenotype	0.70
CELL DEATH	regulates	phenotype	0.70
CREB	treats	gene	0.70
DNA	disrupts	gene	0.70
neurons	activates	cell_type	0.70
unfolded protein response	participates_in	pathway	0.70
senescence	participates_in	pathway	0.70
epigenetic regulation	participates_in	pathway	0.70
APOE	activates	gene	0.65

Incoming (419)

Source	Relation	Type	Str
DNA	activates	gene	1.00
CANCER	activates	gene	1.00
TP53	inhibits	gene	0.80
INFLAMMATION	activates	gene	0.80
P53	activates	gene	0.80
CANCER	associated_with	gene	0.70
CANCER	therapeutic_target	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
CYTOKINES	activates	gene	0.70
CANCER	inhibits	gene	0.70
NF-ΚB	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
GENES	activates	gene	0.70
GENES	inhibits	gene	0.70
DNA	inhibits	gene	0.70
ATG	activates	gene	0.70
ATG	regulates	gene	0.70
FERROPTOSIS	causes	phenotype	0.70
AUTOPHAGY	transports	phenotype	0.65
FERROPTOSIS	interacts_with	phenotype	0.65
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60
STING1	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
POLG	associated_with	gene	0.60
RAD54	activates	gene	0.60
VCP	activates	gene	0.60
RAD51	activates	gene	0.60
ATR	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATM

Understanding Entity Pages

Summary

Wiki Pages (21)

ATM Gene

cbs-psp-daily-action-plan

primary-progressive-aphasia

NPM1 Gene

Non-Homologous End Joining in Neurodegeneration

DNA Damage Response in Parkinson's Disease

Pathway Diagram

Outgoing (981)

Incoming (419)

Targeting Hypotheses (0)

Mentioning Analyses (4)

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

What biomarkers can reliably detect microglial priming states in living patients

Related Papers (0)

ATM

Understanding Entity Pages

Summary

Wiki Pages (21)

ATM Gene

cbs-psp-daily-action-plan

primary-progressive-aphasia

NPM1 Gene

Non-Homologous End Joining in Neurodegeneration

DNA Damage Response in Parkinson's Disease

TYNDASE — Tyndall

DNA Damage Response in Corticobasal Syndrome

DNA Damage Response Impairment Pathway

NF-kB Signaling Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

dna-damage-repair

DDB2 Gene

Histone Modification Pathways in Neurodegeneration

DNA Damage Response in Alzheimer's Disease

Cellular Senescence in Neurodegeneration

ftd-tdp43-pathway

Mechanisms Dashboard

FBXO3 Protein

PAK2 Protein (p21-Activated Kinase 2)

Neuroacanthocytosis Syndromes

Pathway Diagram

Outgoing (981)

Incoming (419)

Targeting Hypotheses (0)

Mentioning Analyses (4)

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

What biomarkers can reliably detect microglial priming states in living patients

Related Papers (0)