protein

ATM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1360Connections

9Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATM is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 589 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATM
Full Name	Ataxia-Telangiectasia Mutated
Chromosome	11q22.3
Protein Type	Serine/Threonine Kinase
Function	is a PIKK-family serine/threonine kinase that coordinates genomic stress responses, especially after DNA double-strand breaks.
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Dna Damage Response
UniProt ID	[Q13315](https://www.uniprot.org/uniprotkb/Q13315)
Ensembl ID	ENSG00000149311
GeneCards	ATM
Human Protein Atlas	ATM
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	mtDNA, rapamycin
Interactions	ABCD3, ACETYL-COA, Actin, AGING, AKT, ALOX
KG Connections	1359 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATM Gene

gene · 887 words

→

Validated Hypothesis: ATM Kinase Hyperactivation Triggers DNA Damage Response Overflow and p53-Dependent Motor Neuron Apoptosis in ALS

hypothesis · 1139 words

→

Pathway Diagram

graph TD
    ATM["ATM"] -->|"expressed in"| synaptic_vesicles["synaptic vesicles"]
    ATM["ATM"] -->|"expressed in"| endosomes["endosomes"]
    ATM["ATM"] -->|"expressed in"| lysosomes["lysosomes"]
    ATM["ATM"] -->|"interacts"| ATR["ATR"]
    ATM["ATM"] -->|"interacts"| Dementia["Dementia"]
    ATM["ATM"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    CAT["CAT"] -->|"interacts"| ATM["ATM"]
    OPTN["OPTN"] -->|"interacts"| ATM["ATM"]
    DNM1L["DNM1L"] -->|"interacts"| ATM["ATM"]
    CANX["CANX"] -->|"interacts"| ATM["ATM"]
    style ATM fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (949)

Target	Relation	Type	Str
ATM	encodes	protein	0.00
Cancer	activates	disease	1.00
Tumor	associated_with	disease	0.90
Senescence	activates	disease	0.85
RFWD3	phosphorylates	gene	0.85
Tumor	inhibits	disease	0.85
Als	activates	disease	0.85
Inflammation	activates	disease	0.85
Ataxia	activates	disease	0.85
neural stem cells	regulates	cell_type	0.80
neural stem cells	activates	cell_type	0.80
autophagy pathway	participates_in	pathway	0.80
Ferroptosis	associated_with	process	0.80
DLBCL	biomarker_for	disease	0.80
Als	inhibits	disease	0.75
Aging	activates	disease	0.75
mtDNA	modulates	compound	0.75
Mitochondrial dysfunction	associated_with	phenotype	0.75
Cancer	associated_with	disease	0.75
Als	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Cancer	inhibits	disease	0.75
ATR	interacts_with	protein	0.70
epigenetic regulation	participates_in	pathway	0.70
neurons	activates	cell_type	0.70
unfolded protein response	participates_in	pathway	0.70
lysosomes	expressed_in	cell_type	0.70
endosomes	expressed_in	cell_type	0.70
Apoptosis	therapeutic_target	pathway	0.70
synaptic vesicles	expressed_in	cell_type	0.70
DNA	disrupts	gene	0.70
senescence	participates_in	pathway	0.70
Apoptosis	activates	pathway	0.70
Ferroptosis	activates	pathway	0.70
CELL DEATH	regulates	phenotype	0.70
Dna Repair	activates	pathway	0.70
Nf-Κb	activates	pathway	0.70
Autophagy-Lysosomal Pathway	regulates	process	0.70
CREB	treats	gene	0.70
TNF	stabilizes	gene	0.70
TNF	inhibits	gene	0.70
Mapk	activates	pathway	0.70
STING1	regulates	gene	0.70
Autophagy	activates	pathway	0.70
ULK1	activates	gene	0.70
LC3	regulates	gene	0.70
AUTOPHAGY	associated_with	phenotype	0.70
MAP1LC3B	regulates	gene	0.70
TDP-43	regulates	gene	0.70
Dna Damage Response	associated_with	pathway	0.70

Incoming (411)

Source	Relation	Type	Str
ATM	encodes	gene	0.00
DNA	activates	gene	1.00
CANCER	activates	gene	1.00
TP53	inhibits	gene	0.80
P53	activates	gene	0.80
INFLAMMATION	activates	gene	0.80
GENES	inhibits	gene	0.70
DNA	inhibits	gene	0.70
CANCER	associated_with	gene	0.70
CANCER	therapeutic_target	gene	0.70
CYTOKINES	activates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
CANCER	inhibits	gene	0.70
ATG	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
NF-ΚB	activates	gene	0.70
GENES	activates	gene	0.70
ATG	regulates	gene	0.70
FERROPTOSIS	causes	phenotype	0.70
AUTOPHAGY	transports	phenotype	0.65
FERROPTOSIS	interacts_with	phenotype	0.65
CGAS	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
POLG	associated_with	gene	0.60
MFN1	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
BMAL1	associated_with	gene	0.60
STING1	associated_with	gene	0.60
AMBRA1	activates	entity	0.60
FANCD2	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
WFS1	associated_with	gene	0.60
HARS	associated_with	gene	0.60
MRE11	activates	gene	0.60
PTEN	regulates	gene	0.60
SMAC	activates	gene	0.60
BID	regulates	gene	0.60
ATR	regulates	gene	0.60
H2AX	therapeutic_target	gene	0.60
TBK1	activates	gene	0.60
CDKN2A	associated_with	gene	0.60
TP53	associated_with	gene	0.60
AKT	contributes_to	gene	0.60
PIK3CA	associated_with	gene	0.60
SOX2	biomarker_for	gene	0.60
TMEM173	associated_with	gene	0.60
MTOR	biomarker_for	gene	0.60
PTK2B	associated_with	gene	0.60
GATA2	therapeutic_target	gene	0.60

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ATM Kinase Hyperactivation Triggers DNA Damage Response Over	0.837	als	-
C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD	0.720	neurodegeneration	Test Hypothesis Fixtures
Multi-Biomarker Composite Index Surpassing Amyloid PET for T	0.579	neurodegeneration	Multi-modal Biomarker Panel Design for E
Dynamic Microglial Phenotype Switching Biomarker Panel for N	0.577	neurodegeneration	What amyloid threshold level is required
Optogenetic restoration of hippocampal gamma oscillations vi	0.555	alzheimers	Circuit-level neural dynamics in neurode

Combined p-tau217 + p-tau231 Panel Increases Specificity for	0.546	neurodegeneration	-
CSF p-tau217 Threshold of <0.15 pg/mL Predicts Durable Clini	0.512	neurodegeneration	-
Rational design of small molecules targeting TDP-43 liquid-t	0.510	neurodegeneration	Test
Hyaluronidase Treatment Disrupts Perivascular Inflammatory N	0.000	-	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567]	Guerreiro S, Privat AL, Bressac L, Toulo	Cells	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567]	Guerreiro S, Privat AL, Bressac L, Toulo	Cells	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATM in their description or question text

Rational design of small molecules targeting TDP-43 liquid-to-solid phase transi

Score: 0.510 · neurodegeneration · 2026-05-01

TDP-43 undergoes pathological liquid-liquid phase separation in ALS/FTD, and small molecules that restore liquid-like pr

Hyaluronidase Treatment Disrupts Perivascular Inflammatory Niches

Score: 0.000 · unknown disease · 2026-04-28

Reactive astrocytes deposit hyaluronic acid that traps inflammatory mediators in perivascular spaces, creating persisten